Anna L. Tyler
Dartmouth College
31 Papers
55 Citations
Anna L. Tyler is an academic researcher from Dartmouth College. The author has contributed to research in topics: Epistasis & Genetic architecture. The author has an hindex of 11, co-authored 27 publications.
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Papers
Speed modulation of hippocampal theta frequency correlates with spatial memory performance
Gregory R. Richard,Ali S Titiz,Anna L. Tyler,Gregory L. Holmes,Rod C. Scott,Pierre-Pascal Lenck-Santini +5 more
TL;DR: Investigating whether hippocampal speed‐theta integration influences spatial memory and whether it could account for the memory deficits observed in TLE rats reveals that speed/theta frequency correlation with performance cannot merely be explained by the direct influence of speed on behavior.
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SLC39A2 and FSIP1 polymorphisms as potential modifiers of arsenic-related bladder cancer.
Margaret R. Karagas,Angeline S. Andrew,Heather H. Nelson,Zhongze Li,Tracy Punshon,Alan R. Schned,Carmen J. Marsit,J. Steven Morris,Jason H. Moore,Anna L. Tyler,Diane Gilbert-Diamond,Mary Lou Guerinot,Karl T. Kelsey +12 more
TL;DR: Novel variants that may influence risk of arsenic-associated bladder cancer and those who may be at greatest risk from this widespread exposure are suggested.
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Functional Network Changes in Hippocampal CA1 after Status Epilepticus Predict Spatial Memory Deficits in Rats
Anna L. Tyler,J. M. Mahoney,Gregory R. Richard,Gregory L. Holmes,Pierre-Pascal Lenck-Santini,Rod C. Scott +5 more
TL;DR: In vivo single-unit activity in the CA1 hippocampal region of rats while they performed a spatial memory task provides a physiological mechanism for SE-induced cognitive impairment and highlights the importance of the systems-level perspective in investigating spatial cognition.
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A genetic interaction network model of a complex neurological disease
TL;DR: Combined analysis of pleiotropy and epistasis (CAPE) is used to detect and interpret genetic interactions in a meta‐population derived from three C3H × B6J strain crosses, each of which is fixed for a different SWD‐causing mutation.
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Transcriptomic Stratification of Late-Onset Alzheimer\'s Cases Reveals Novel Genetic Modifiers of Disease Pathology
Nikhil Milind,Christoph Preuss,Annat Haber,Guruprasad Ananda,Shubhabrata Mukherjee,Cai John,Sarah Shapley,Anna L. Tyler,Benjamin A. Logsdon,Paul K. Crane,Gregory W. Carter +10 more
TL;DR: A novel approach to define relevant transcriptomic endophenotypes and stratify decedents based on molecular profiles in three independent human LOAD cohorts and single variant association analysis identified a genome-wide significant variant in TMEM106B in the ROSMAP cohort that confers protection from the inflammatory LOAD subtype.