Filtered back projection (FBP) has been the standard CT image reconstruction method for 4 decades. A simple, fast, and reliable technique, FBP has delivered high-quality images in several clinical applications. However, with faster and more advanced CT scanners, FBP has become increasingly obsolete. Higher image noise and more artifacts are especially noticeable in lower-dose CT imaging using FBP. This performance gap was partly addressed by model-based iterative reconstruction (MBIR). Yet, its "plastic" image appearance and long reconstruction times have limited widespread application. Hybrid iterative reconstruction partially addressed these limitations by blending FBP with MBIR and is currently the state-of-the-art reconstruction technique. In the past 5 years, deep learning reconstruction (DLR) techniques have become increasingly popular. DLR uses artificial intelligence to reconstruct high-quality images from lower-dose CT faster than MBIR. However, the performance of DLR algorithms relies on the quality of data used for model training. Higher-quality training data will become available with photon-counting CT scanners. At the same time, spectral data would greatly benefit from the computational abilities of DLR. This review presents an overview of the principles, technical approaches, and clinical applications of DLR, including metal artifact reduction algorithms. In addition, emerging applications and prospects are discussed.

Deep Learning Image Reconstruction for CT: Technical Principles and Clinical Prospects.

Computed tomography (CT) dramatically improved the capabilities of diagnostic and interventional radiology. Starting in the early 1970s, this imaging modality is still evolving, although tremendous improvements in scan speed, volume coverage, spatial and soft tissue resolution, as well as dose reduction have been achieved. Tube current modulation, automated exposure control, anatomy-based tube voltage (kV) selection, advanced x-ray beam filtration, and iterative image reconstruction techniques improved image quality and decreased radiation exposure. Cardiac imaging triggered the demand for high temporal resolution, volume acquisition, and high pitch modes with electrocardiogram synchronization. Plaque imaging in cardiac CT as well as lung and bone imaging demand for high spatial resolution. Today, we see a transition of photon-counting detectors from experimental and research prototype setups into commercially available systems integrated in patient care. Moreover, with respect to CT technology and CT image formation, artificial intelligence is increasingly used in patient positioning, protocol adjustment, and image reconstruction, but also in image preprocessing or postprocessing. The aim of this article is to give an overview of the technical specifications of up-to-date available whole-body and dedicated CT systems, as well as hardware and software innovations for CT systems in the near future. 

Computed Tomography 2.0

Coronary heart disease (CHD) is the leading cause of mortality in the world. Early detection and treatment of CHD are crucial. Currently, coronary CT angiography (CCTA) has been the prior choice for CHD screening and diagnosis, but it cannot meet the clinical needs in terms of examination quality, the accuracy of reporting, and the accuracy of prognosis analysis. In recent years, artificial intelligence (AI) has developed rapidly in the field of medicine; it played a key role in auxiliary diagnosis, disease mechanism analysis, and prognosis assessment, including a series of studies related to CHD. In this article, the application and research status of AI in CCTA were summarized and the prospects of this field were also described.

https://www.frontiersin.org/articles/10.3389/fcvm.2022.896366/pdf

Artificial Intelligence in Coronary CT Angiography: Current Status and Future Prospects

Improving image quality with super-resolution deep-learning-based reconstruction in coronary CT angiography.

https://doi.org/10.1016/j.jacasi.2022.12.005

Advances in Diagnosis, Therapy, and Prognosis of Coronary Artery Disease Powered by Deep Learning Algorithms

Deep-learning image reconstruction (DLIR) offers unique opportunities for reducing image noise without degrading image quality or diagnostic accuracy in coronary CT angiography (CCTA). The present study aimed at exploiting the capabilities of DLIR to reduce radiation dose and assess its impact on stenosis severity, plaque composition analysis, and plaque volume quantification. This prospective study includes 50 patients who underwent two sequential CCTA scans at normal-dose (ND) and lower-dose (LD). ND scans were reconstructed with Adaptive Statistical Iterative Reconstruction-Veo (ASiR-V) 100%, and LD scans with DLIR. Image noise (in Hounsfield units, HU) and quantitative plaque volumes (in mm3) were assessed quantitatively. Stenosis severity was visually categorized into no stenosis (0%), stenosis (< 20%, 20–50%, 51–70%, 71–90%, 91–99%), and occlusion (100%). Plaque composition was classified as calcified, non-calcified, or mixed. Reduction of radiation dose from ND scans with ASiR-V 100% to LD scans with DLIR at the highest level (DLIR-H; 1.4 mSv vs. 0.8 mSv, p < 0.001) had no impact on image noise (28 vs. 27 HU, p = 0.598). Reliability of stenosis severity and plaque composition was excellent between ND scans with ASiR-V 100% and LD scans with DLIR-H (intraclass correlation coefficients of 0.995 and 0.974, respectively). Comparison of plaque volumes using Bland–Altman analysis revealed a mean difference of − 0.8 mm3 (± 2.5 mm3) and limits of agreement between − 5.8 and + 4.1 mm3. DLIR enables a reduction in radiation dose from CCTA by 43% without significant impact on image noise, stenosis severity, plaque composition, and quantitative plaque volume. •Deep-learning image reconstruction (DLIR) enables radiation dose reduction by over 40% for coronary computed tomography angiography (CCTA). •Image noise remains unchanged between a normal-dose CCTA reconstructed by ASiR-V and a lower-dose CCTA reconstructed by DLIR. •There is no impact on the assessment of stenosis severity, plaque composition, and quantitative plaque volume between the two scans.

/pdf/radiation-dose-reduction-with-deep-learning-image-mhegsqh4em.pdf

Radiation dose reduction with deep-learning image reconstruction for coronary computed tomography angiography

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Radiation dose reduction with deep-learning image reconstruction for coronary computed tomography angiography