Anna K. Koster
Stanford University
6 Papers
11 Citations
Anna K. Koster is an academic researcher from Stanford University. The author has contributed to research in topics: Gating & GlueX. The author has an hindex of 2, co-authored 6 publications.
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Papers
A selective class of inhibitors for the CLC-Ka chloride ion channel
Anna K. Koster,Chase Wood,Rhiannon Thomas-Tran,Tanmay S. Chavan,Jonas Almqvist,Kee-Hyun Choi,J. Du Bois,Merritt Maduke +7 more
TL;DR: The design, synthesis, and evaluation of a collection of N-arylated benzimidazole derivatives (BIMs), one of which (BIM1) shows unparalleled (>20-fold) selectivity for C LC-Ka over CLC-Kb, the two most closely related human CLC homologs are described.
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Dynamical model of the CLC-2 ion channel reveals conformational changes associated with selectivity-filter gating.
TL;DR: A dynamical Markov state model of CLC-2 “fast” (pore) gating, based on 600 microseconds of molecular dynamics simulation, is reported, which provides a high-resolution structural model to guide future investigations.
Dynamical model of the CLC-2 ion channel reveals conformational changes associated with selectivity-filter gating
TL;DR: A dynamical Markov state model of CLC-2 “fast” (pore) gating, based on 600 microseconds of molecular dynamics simulation, is reported, which provides a high-resolution structural model to guide future investigations of C LC-2.
Dynamical model of the CLC-2 ion channel exhibits a two-step gating mechanism
TL;DR: A Markov state model of the conformational dynamics involved in regulating the inner and outer gates of the CLC-2 ion channel suggests a new mechanism for channel activation and highlights a dominant pathway between a highly stable closed state and several new protein conformations not observed in any previously elucidated CLC structure.
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Development and validation of a potent and specific inhibitor provides evidence for the CLC-2 chloride channel as a potential epilepsy target
Anna K. Koster,Austin L. Reese,Yuri A. Kuryshev,Xianlan Wen,Adam C Lu,Keri A. McKiernan,Erin E. Gray,Caiyun Wu,Mark P. Beenhakker,John R. Huguenard,Merritt Maduke,J. Du Bois +11 more
TL;DR: The development and optimization of a new small-molecule inhibitor of CLC-2, AK-42, that exhibits unprecedented potency and specificity are described and established as a powerful new tool for investigating C LC-2 physiology in the central nervous system.