Anna K. Böttiger
Örebro University
10 Papers
64 Citations
Anna K. Böttiger is an academic researcher from Örebro University. The author has contributed to research in topics: Methylenetetrahydrofolate reductase & Pyrosequencing. The author has an hindex of 6, co-authored 10 publications.
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Papers
Association of total plasma homocysteine with methylenetetrahydrofolate reductase genotypes 677C>T, 1298A>C, and 1793G>A and the corresponding haplotypes in Swedish children and adolescents.
TL;DR: A haplotype-based approach was slightly superior in explaining the genetic interaction on tHcy plasma levels in children and adolescents than a simple genotype based approach.
Genetic variation in the folate receptor-alpha and methylenetetrahydrofolate reductase genes as determinants of plasma homocysteine concentrations
Anna K. Böttiger
- 01 Jan 2008
TL;DR: The B vitamins folate and B12 are the main de terminants of tHcy, which is a risk factor for cardiovascular disease and neurocognitive disease such as dementia.
MTHFR polymorphisms and serum cobalamin affect plasma homocysteine concentrations differentially in females and males
TL;DR: It was concluded that gene‑nutrient interactions may differ depending on the sex and age of the subjects, and the transferability of gene‑Nutrient interactions from one community to others may be limited not only by different food patterns but also by different ages, genders and genotype distributions.
Mutations in exons 2 and 3 of the FOLR1 gene in demented and non-demented elderly subjects
TL;DR: 8 novel rare FOLR1 mutations with a combined prevalence of approximately 1.3% in Whites as well as two common polymorphisms with 5% and 13%, respectively, have been demonstrated and a few of the rare mutations may potentially be associated with raised plasma tHcy concentrations.
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Genotyping of the reduced folate carrier-1 c.80G>A polymorphism by pyrosequencing technology: importance of PCR and pre-PCR optimization.
TL;DR: It is concluded that, with these modifications, the RFC1 c.80G>A SNP can be reliably assayed by pyrosequencing.
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