Anna Holmström
Umeå University
18 Papers
487 Citations
Anna Holmström is an academic researcher from Umeå University. The author has contributed to research in topics: Yersinia pseudotuberculosis & Hantavirus. The author has an hindex of 14, co-authored 17 publications. Previous affiliations of Anna Holmström include Swedish Defence Research Agency.
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Papers
The V-antigen of Yersinia is surface exposed before target cell contact and involved in virulence protein translocation :
Jonas Pettersson,Anna Holmström,Jim Hill,Sophie Emma Clare Leary,Elisabet Frithz-Lindsten,Anne von Euler-Matell,Eva Carlsson,Richard W. Titball,Åke Forsberg,Hans Wolf-Watz +9 more
TL;DR: It is shown that anti‐LcrV antibodies can block the delivery of Yop effectors into the target cell cytosol, suggesting that LcrV serves an important role in the initiation of the translocation process and provides one possible explanation for the mechanism of LCrV‐induced protective immunity.
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YopK of Yersinia pseudotuberculosis controls translocation of Yop effectors across the eukaryotic cell membrane.
Anna Holmström,Jonas Petterson,Roland Rosqvist,Sebastian Håkansson,Farideh Tafazoli,Maria Fällman,Karl-Eric Magnusson,Hans Wolf-Watz,Åke Forsberg +8 more
TL;DR: A model where YopK controls the translocation of Yop effectors into eukaryotic cells is proposed, which is similar to YopB, localized to cell‐associated bacteria during infection of HeLa cells.
151
LcrV is a channel size-determining component of the Yop effector translocon of Yersinia
Anna Holmström,Jan Olsson,Peter Cherepanov,Elke Maier,Roland Nordfelth,Jonas Pettersson,Roland Benz,Hans Wolf-Watz,Åke Forsberg +8 more
TL;DR: The size of the channel correlated with the ability to translocate Yop effectors into host cells and it is suggested that LcrV is a size‐determining structural component of the Yop translocon.
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Functional conservation of the effector protein translocators PopB/YopB and PopD/YopD of Pseudomonas aeruginosa and Yersinia pseudotuberculosis
Elisabet Frithz-Lindsten,Anna Holmström,Lars Jacobsson,Mehnam Soltani,Jan Olsson,Roland Rosqvist,Åke Forsberg +6 more
TL;DR: The findings show that the contact‐dependent toxin‐targeting mechanisms of Y. pseudotuberculosis and P. aeruginosa are conserved at the molecular level and that the translocator proteins are functionally interchangeable.
107
Apically Exposed, Tight Junction-Associated β1-Integrins Allow Binding and YopE-Mediated Perturbation of Epithelial Barriers by Wild-Type Yersinia Bacteria
TL;DR: It is concluded that the Yersinia bacteria attach to β1-integrins at tight junctions, and via this localized injection of YopE, they perturb the F-actin structure and distribution of proteins forming and regulating close junctions and promote paracellular translocation of bacteria and soluble compounds.
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