Anna Henry
University of Melbourne
10 Papers
371 Citations
Anna Henry is an academic researcher from University of Melbourne. The author has contributed to research in topics: Amyloid precursor protein & Amyloid precursor protein secretase. The author has an hindex of 9, co-authored 10 publications. Previous affiliations of Anna Henry include Mental Health Research Institute.
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Papers
Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein.
Jamie Rossjohn,Roberto Cappai,Roberto Cappai,Susanne C. Feil,Anna Henry,Anna Henry,William J. McKinstry,Denise Galatis,Denise Galatis,Lars Hesse,Gerd Multhaup,Konrad Beyreuther,Colin L. Masters,Colin L. Masters,Michael W. Parker +14 more
TL;DR: Structural similarities with cysteine-rich growth factors, taken together with its known growth-promoting properties, suggests the APP N-terminal domain could function as a growth factor in vivo.
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Relative Increase in Alzheimer’s Disease of Soluble Forms of Cerebral Aβ Amyloid Protein Precursor Containing the Kunitz Protease Inhibitory Domain
Robert D. Moir,Toni Lynch,Ashley I. Bush,Scott Whyte,Anna Henry,Stuart Portbury,Gerd Multhaup,David H. Small,Rudolph E. Tanzi,Konrad Beyreuther,Colin L. Masters +10 more
TL;DR: An imbalance of isoforms as one possible mechanism for amyloid deposition in sporadic AD is supported, and KPI-containing species of APP may be more amyloidsogenic.
112
Recombinant human amyloid precursor-like protein 2 (APLP2) expressed in the yeast Pichia pastoris can stimulate neurite outgrowth
Roberto Cappai,Su San Mok,Denise Galatis,David F. B. Tucker,Anna Henry,Konrad Beyreuther,David H. Small,Colin L. Masters +7 more
TL;DR: The neuritotrophic activity of APLP2 was compared to the APP isoforms sAPP695 and sAPP751 on chick sympathetic neurones and it was suggested that APP andAPLP2 have a similar or related role and supports the idea of a redundancy in function between the APP‐gene family proteins.
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Inhibition of platelet activation by the Alzheimer's disease amyloid precursor protein
Anna Henry,Qiao-Xin Li,Denise Galatis,Lars Hesse,Gerd Multhaup,Konrad Beyreuther,Colin L. Masters,Roberto Cappai +7 more
TL;DR: Evidence is provided that the release of sAPP upon platelet degranulation may result in negative feedback regulation during platelet activation, which suggests that sAPP decreases the availability of free AA, although the mechanism is not yet known.
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Processing of the Alzheimer's disease amyloid precursor protein in Pichia pastoris: immunodetection of alpha-, beta-, and gamma-secretase products.
D. Le Brocque,Anna Henry,Roberto Cappai,Qiao-Xin Li,J.E. Tanner,Denise Galatis,C Gray,S. Holmes,John R. Underwood,Konrad Beyreuther,Colin L. Masters,Genevieve Evin +11 more
TL;DR: Results suggest that the alpha-, beta-, and gamma-secretase cleavages are conserved in yeast and that P. pastoris may offer an alternative to mammalian cells to identify the proteases involved in the generation of AD betaA4 amyloid.
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