Anna Elliott
Institute of Cancer Research
18 Papers
15 Citations
Anna Elliott is an academic researcher from Institute of Cancer Research. The author has contributed to research in topics: Exome & Exome sequencing. The author has an hindex of 13, co-authored 18 publications.
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Papers
PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene
Nazneen Rahman,Sheila Seal,Deborah J. Thompson,Patrick Kelly,Anthony Renwick,Anna Elliott,Sarah Reid,Katarina Spanova,Rita Barfoot,Tasnim Chagtai,Hiran Jayatilake,Lesley McGuffog,Sandra Hanks,D. Gareth Evans,Diana Eccles,Douglas F. Easton,Michael R. Stratton +16 more
TL;DR: The results show that PALB2 is a breast cancer susceptibility gene and further demonstrate the close relationship of the Fanconi anemia–DNA repair pathway and breast cancer predisposition.
Truncating mutations in the Fanconi anemia J gene BRIP1 are low-penetrance breast cancer susceptibility alleles
Sheila Seal,Deborah J. Thompson,Anthony Renwick,Anna Elliott,Patrick Kelly,Rita Barfoot,Tasnim Chagtai,Hiran Jayatilake,Munaza Ahmed,Katarina Spanova,Bernard North,Lesley McGuffog,D. Gareth Evans,Diana Eccles,Douglas F. Easton,Michael R. Stratton,Nazneen Rahman +16 more
TL;DR: Inactivating truncating mutations of BRIP1, similar to those in BRCA2, cause Fanconi anemia in biallelic carriers and confer susceptibility to breast cancer in monoallelic carriers.
771
Mutations in Epigenetic Regulation Genes Are a Major Cause of Overgrowth with Intellectual Disability
Katrina Tatton-Brown,Katrina Tatton-Brown,Chey Loveday,Shawn Yost,Matthew Clarke,Emma Ramsay,Anna Zachariou,Anna Elliott,Harriet Wylie,Anna Ardissone,Olaf Rittinger,Fiona Stewart,I. Karen Temple,Trevor Cole,Shazia Mahamdallie,Sheila Seal,Elise Ruark,Nazneen Rahman +17 more
TL;DR: Insight is revealed into the genetic control of human growth and exome sequencing in OGID has a high diagnostic yield, and functional network analyses demonstrated that epigenetic regulation is a prominent biological process dysregulated in individuals with OGID.
181
Identification of new Wilms tumour predisposition genes: an exome sequencing study.
Shazia Mahamdallie,Shawn Yost,Emma Poyastro-Pearson,Esty Holt,Anna Zachariou,Sheila Seal,Anna Elliott,Matthew Clarke,Margaret Warren-Perry,Sandra Hanks,John Anderson,Simon Bomken,Trevor Cole,Roula Farah,Rhoikos Furtwaengler,Adam Glaser,Richard Grundy,James Hayden,Steve Lowis,Frédéric Millot,James Nicholson,Milind Ronghe,Jane Skeen,Denise Williams,Daniel Yeomanson,Elise Ruark,Nazneen Rahman +26 more
TL;DR: The four new Wilms tumour predisposition genes identified—TRIM28, FBXW7, NYNRIN, and KDM3B—are involved in diverse biological processes and, together with the other 17 known Wilms metastatic tumours genes, account for about 10% of Wiltshire tumour cases.
122
Germline mutations in the PAF1 complex gene CTR9 predispose to Wilms tumour
Sandra Hanks,Elizabeth R Perdeaux,Sheila Seal,Elise Ruark,Shazia Mahamdallie,Anne Murray,Emma Ramsay,Silvana Del Vecchio Duarte,Anna Zachariou,Bianca de Souza,Margaret Warren-Perry,Anna Elliott,Alan Davidson,Helen Price,Charles A. Stiller,Kathy Pritchard-Jones,Nazneen Rahman +16 more
TL;DR: Inactivating CTR9 mutations in 3 of 35 Wilms tumour families are identified and these data establish CTR9 as a Wilms cancer predisposition gene and suggest it acts as a tumour suppressor gene.