Anna E. Stepien
Friedrich Miescher Institute for Biomedical Research
6 Papers
Anna E. Stepien is an academic researcher from Friedrich Miescher Institute for Biomedical Research. The author has contributed to research in topics: Interneuron & Gene. The author has an hindex of 4, co-authored 4 publications. Previous affiliations of Anna E. Stepien include University of Basel.
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Papers
Monosynaptic Rabies Virus Reveals Premotor Network Organization and Synaptic Specificity of Cholinergic Partition Cells
TL;DR: An anatomical rabies virus-based connectivity assay in early postnatal mice is established to study the connectivity scheme of premotor neurons, the neuronal cohorts monosynaptically connected to motor neurons, unveiling three aspects of organization.
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Goal-directed vocal planning in a songbird
TL;DR: Targeted vocal plasticity does not require immediate sensory experience, showing that zebra finches are capable of goal-directed vocal planning and making target-directed changes to their songs without requiring sensory feedback.
Motor antagonism exposed by spatial segregation and timing of neurogenesis
TL;DR: It is found that proprioceptive sensory feedback from the periphery is targeted to medial extensor premotor populations and is required for extensor-specific connectivity profiles during development, providing evidence for a discriminating anatomical basis of antagonistic circuits at the level of premotor interneurons.
Optogenetic Dissection of Neuronal Circuits in Zebrafish using Viral Gene Transfer and the Tet System
Peixin Zhu,Yuichi Narita,Sebastian Bundschuh,Otto Fajardo,Yan-Ping Zhang Schärer,Bidisha Chattopadhyaya,Estelle Arn Bouldoires,Anna E. Stepien,Anna E. Stepien,Karl Deisseroth,Silvia Arber,Silvia Arber,Rolf Sprengel,Filippo M. Rijli,Rainer W. Friedrich +14 more
TL;DR: Two complementary methods, viral gene delivery and the iTet-Off system, are explored to express transgenes in the brain of zebrafish to provide new opportunities for the optogenetic dissection of neuronal circuit structure and function.
Probing the locomotor conundrum: descending the 'V' interneuron ladder.
Anna E. Stepien,Silvia Arber +1 more
TL;DR: The assembly of neuronal circuits involved in locomotor control in the mammalian spinal cord is influenced by genetic programs specifying four ventral interneuron populations (V0-V3), and genetic tools are used to map connectivity patterns and to abolish the function of V2a and V3 interneurons.