Anna Comel
AREA Science Park
5 Papers
4 Citations
Anna Comel is an academic researcher from AREA Science Park. The author has contributed to research in topics: Mitochondrion & Programmed cell death. The author has an hindex of 4, co-authored 5 publications. Previous affiliations of Anna Comel include University of Trieste.
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Papers
BRD7 is a candidate tumour suppressor gene required for p53 function.
Jarno Drost,Fiamma Mantovani,Fiamma Mantovani,Francesca Tocco,Francesca Tocco,Ran Elkon,Anna Comel,Anna Comel,Henne Holstege,Ron M. Kerkhoven,Jos Jonkers,P. Mathijs Voorhoeve,P. Mathijs Voorhoeve,Reuven Agami,Giannino Del Sal,Giannino Del Sal +15 more
TL;DR: BRD7 (bromodomain-containing 7) is identified as a protein whose inhibition allows full neoplastic transformation in the presence of wild-type p53, and suppresses tumorigenicity by serving as a p53 cofactor required for the efficient induction of p53-dependent oncogene-induced senescence.
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Regulation of mitochondrial apoptosis by Pin1 in cancer and neurodegeneration.
TL;DR: The impact of Pin1 in regulating various aspects of apoptosis in different biological contexts with particular emphasis on cancer and neurodegenerative diseases is discussed.
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p53 orchestrates calcium signaling in vivo.
TL;DR: P53 localizes at ER and at mitochondria-associated membranes (MAMs), and upon activation by a variety of stimuli, is able to bind the sarco/ER Ca2+-ATPase (SERCA) pump, leading to an increase ofCa2+ release from the ER and a consequent mitochondrial Ca2-dependent overload that profoundly impacts on the ability of the cells to undergo apoptosis.
4
The cytoplasmic side of p53’s oncosuppressive activities
TL;DR: This review will focus on the mechanisms of cytoplasmic p53 activation and the pathophysiological role of p53's transcription‐independent functions, highlighting possible therapeutic implications.
Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin
Alice Grison,Fiamma Mantovani,Anna Comel,Elena Agostoni,Stefano Gustincich,Francesca Persichetti,Giannino Del Sal +6 more
TL;DR: The pathway of p53 activation by mHtt is dissected, providing a rationale for the use of small-molecule inhibitors of stress-responsive protein kinases and Pin1 as a potential therapeutic strategy for HD treatment.