Anna Chalupka
Lund University
6 Papers
Anna Chalupka is an academic researcher from Lund University. The author has contributed to research in topics: Antimicrobial peptides & Biology. The author has an hindex of 6, co-authored 6 publications. Previous affiliations of Anna Chalupka include Jagiellonian University.
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Papers
Proteolysis of human thrombin generates novel host defense peptides.
Praveen Papareddy,Victoria Rydengård,Mukesh Pasupuleti,Björn Walse,Matthias Mörgelin,Anna Chalupka,Anna Chalupka,Martin Malmsten,Artur Schmidtchen +8 more
TL;DR: These findings provide a novel link between the coagulation system and host-defense peptides, two fundamental biological systems activated in response to injury and microbial invasion.
Boosting antimicrobial peptides by hydrophobic oligopeptide end tags.
Artur Schmidtchen,Mukesh Pasupuleti,Matthias Mörgelin,Mina Davoudi,Jan Alenfall,Anna Chalupka,Martin Malmsten +6 more
TL;DR: The generality of end tagging for facile boosting of antimicrobial peptides without the need for post-synthesis modification was demonstrated, and tagging resulted in enhanced killing of Gram-positive Staphylococcus aureus, Gram-negative Escherichia coli, and fungal Candida albicans.
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End-Tagging of Ultra-Short Antimicrobial Peptides by W/F Stretches to Facilitate Bacterial Killing
TL;DR: End-tagging by hydrophobic amino acid stretches may be employed to enhance bactericidal potency also of ultra-short AMPs at maintained limited toxicity, and facilitates straightforward synthesis of hydrophobically modified AMPs without the need for post-peptide synthesis modifications.
Histidine-Rich Glycoprotein Protects from Systemic Candida Infection
Victoria Rydengård,Oonagh Shannon,Katarina Lundqvist,Lukasz A. Kacprzyk,Lukasz A. Kacprzyk,Anna Chalupka,Anna Chalupka,Anna-Karin Olsson,Matthias Mörgelin,Willi Jahnen-Dechent,Martin Malmsten,Artur Schmidtchen +11 more
TL;DR: A novel antifungal role of histidine-rich glycoprotein (HRG), an abundant and multimodular plasma protein, is demonstrated, demonstrating the ability of the innate immune system to control potentially invasive microbes found at biological boundaries.
Antimicrobial activity of human prion protein is mediated by its N-terminal region
Mukesh Pasupuleti,Markus Roupé,Victoria Rydengård,Krystyna Surewicz,Witold K. Surewicz,Anna Chalupka,Martin Malmsten,Ole E. Sørensen,Artur Schmidtchen +8 more
TL;DR: The demonstration of an antimicrobial activity of PrP, localisation of its activity to the N-terminal and heparin-binding region, combined with results showing an increased expression of Prp during wounding, indicate that PrPs could have a previously undisclosed role in host defense.