Anna A. Lauer
Saarland University
26 Papers
29 Citations
Anna A. Lauer is an academic researcher from Saarland University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 5, co-authored 14 publications.
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Papers
Vitamin D and Its Analogues Decrease Amyloid-β (Aβ) Formation and Increase Aβ-Degradation.
Marcus O. W. Grimm,Andrea Thiel,Anna A. Lauer,Jakob Winkler,Johannes Lehmann,Liesa Regner,Christopher Nelke,Daniel Janitschke,Céline Benoist,Olga Streidenberger,Hannah Stötzel,Kristina Endres,Christian Herr,Christoph Beisswenger,Heike S. Grimm,Robert Bals,Frank Lammert,Tobias Hartmann +17 more
TL;DR: Vitamin D and analogues decreased β-secretase activity, not only in mouse brains with mild vitamin D hypovitaminosis, but also in non-deficient mouse brains, suggesting that supplementation of vitamin D or vitamin D analogues might have beneficial effects in AD prevention.
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Mechanistic Link between Vitamin B12 and Alzheimer’s Disease
Anna A. Lauer,Heike S. Grimm,Birgit Apel,Nataliya Golobrodska,Lara Kruse,Elina Ratanski,Noemi Schulten,Laura Schwarze,Thomas Slawik,Saskia Sperlich,Antonia Vohla,Marcus O. W. Grimm +11 more
TL;DR: The important role of vitamin B12 in AD is emphasized, which is particularly important, as even in industrialized countries a large proportion of the population might not be sufficiently supplied with vitamin B 12.
A short isoform of STIM1 confers frequency-dependent synaptic enhancement.
Girish Ramesh,Lukas Jarzembowski,Yvonne Schwarz,Vanessa Poth,Maik Konrad,Mona L. Knapp,Gertrud Schwär,Anna A. Lauer,Marcus O. W. Grimm,Dalia Alansary,Dieter Bruns,Barbara A. Niemeyer +11 more
TL;DR: In this article, a splice variant, called STIM1B, was characterized, which shows exclusive neuronal expression and protein content surpassing conventional STIM 1 in cerebellum and of significant abundance in other brain regions.
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Methylxanthines and Neurodegenerative Diseases: An Update.
Daniel Janitschke,Anna A. Lauer,Cornel M Bachmann,Heike S. Grimm,Tobias Hartmann,Marcus O. W. Grimm +5 more
TL;DR: In this paper, the impact of methylxanthines in neurodegenerative diseases has been extensively studied and several new aspects have been elucidated, such as adenosine receptor antagonism, phosphodiesterase inhibition, effects on the cholinergic system, wnt signaling, histone deacetylase activation and gene regulation.
Effect of Caffeine and Other Methylxanthines on Aβ-Homeostasis in SH-SY5Y Cells.
Daniel Janitschke,Christopher Nelke,Anna A. Lauer,Liesa Regner,Jakob Winkler,Andrea Thiel,Heike S. Grimm,Tobias Hartmann,Marcus Otto Walter Grimm +8 more
- 02 Nov 2019
TL;DR: All MTXs act via the pleiotropic mechanism resulting in decreased Aβ and show beneficial properties with respect to AD in neuroblastoma cells, suggesting thatMTXs should be integrated in a healthy diet rather than be used exclusively to treat or prevent AD.
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