Ann Marie Zavacki
Brigham and Women's Hospital
69 Papers
436 Citations
Ann Marie Zavacki is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Deiodinase & DIO2. The author has an hindex of 34, co-authored 66 publications. Previous affiliations of Ann Marie Zavacki include Warsaw University of Life Sciences & Harvard University.
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Papers
Bile Acids: Natural Ligands for an Orphan Nuclear Receptor
Derek J. Parks,Steven G. Blanchard,Randy K. Bledsoe,Gyan Chandra,Thomas G. Consler,Steven A. Kliewer,Julie B. Stimmel,Timothy M. Willson,Ann Marie Zavacki,David D. Moore,Jürgen M. Lehmann +10 more
TL;DR: Results provide evidence for a nuclear bile acid signaling pathway that may regulate cholesterol homeostasis and modulated interaction of FXR with a peptide derived from steroid receptor coactivator 1.
2.2K
Defects in Adaptive Energy Metabolism with CNS-Linked Hyperactivity in PGC-1α Null Mice
Jiandie D. Lin,Pei Hsuan Wu,Paul T. Tarr,Katrin S. Lindenberg,Julie St-Pierre,Chen-Yu Zhang,Vamsi K. Mootha,Sibylle Jäger,Claudia R. Vianna,Richard M. Reznick,Libin Cui,Monia Manieri,Mi X. Donovan,Zhidan Wu,Marcus P. Cooper,Melina C. Fan,Lindsay M. Rohas,Ann Marie Zavacki,Saverio Cinti,Gerald I. Shulman,Bradford B. Lowell,Dimitri Krainc,Bruce M. Spiegelman +22 more
TL;DR: A central role for PGC-1alpha in the control of energy metabolism is illustrated but also novel systemic compensatory mechanisms and pathogenic effects of impaired energy homeostasis are revealed.
1.2K
Cellular and Molecular Basis of Deiodinase-Regulated Thyroid Hormone Signaling
Balázs Gereben,Ann Marie Zavacki,Scott Ribich,Brian W. Kim,Stephen A. Huang,Warner S. Simonides,Anikó Zeöld,Antonio C. Bianco,Antonio C. Bianco +8 more
TL;DR: It seems clear that deiodinases play a much broader role than once thought, with great ramifications for the control of thyroid hormone signaling during vertebrate development and metamorphosis, as well as injury response, tissue repair, hypothalamic function, and energy homeostasis in adults.
832
Thyroid hormones and skeletal muscle--new insights and potential implications.
TL;DR: How skeletal muscle deiodinase activity might be therapeutically harnessed to improve satellite-cell-mediated muscle repair in patients with skeletal muscle disorders, muscle atrophy or injury is examined.
The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate.
Monica Dentice,Amitabha Bandyopadhyay,Balázs Gereben,Isabelle Callebaut,Marcelo A. Christoffolete,Brian W. Kim,Sahar Nissim,Jean-Paul Mornon,Ann Marie Zavacki,Anikó Zeöld,Luciane P. Capelo,Cyntia Curcio-Morelli,Rogerio S. Ribeiro,John W. Harney,Clifford J. Tabin,Antonio C. Bianco +15 more
TL;DR: ECSWSB-1 mediates a mechanism by which 'systemic' thyroid hormone can effect local control of the Hedgehog–PTHrP negative feedback loop and thus skeletogenesis.