Ann E. Wells
8 Papers
1 Citations
Ann E. Wells is an academic researcher. The author has contributed to research in topics: Biology & Kinship. The author has an hindex of 1, co-authored 3 publications.
Chat about Author
Papers
The Combined Analysis of Pleiotropy and Epistasis (CAPE)
TL;DR: The Combined Analysis of Pleiotropy and Epistasis (CAPE) method as mentioned in this paper combines information across multiple quantitative traits to infer directed epistatic interactions, which can be used to link genetic variants to gene expression, physiological endophenotypes, and higher-level disease traits.
3
Independent and Interactive Effects of Genetic Background and Sex on Tissue Metabolomes of Adipose, Skeletal Muscle, and Liver in Mice
Ann E. Wells,William T. Barrington,Stephen P. Dearth,Nikhil Milind,Gregory T. Carter,David W. Threadgill,Shawn R. Campagna,Brynn H. Voy +7 more
TL;DR: Inbred strains of laboratory mice used to evaluate the impact of genetic variation on the metabolomes of tissues that play central roles in metabolic diseases indicate that genetic variation exerts a fundamental influence on tissue metabolism.
Inhibition of Glycolysis Modifies Distinctive Metabolic and Immune Pathways Across Multiple Tissue Compartments Associated with B and T Follicular Helper Cells
TL;DR: In this paper , the authors show that 2DG has a systemic impact altering immune and metabolic pathways, but in a tissue-specific manner, and three pathway groups, transcription, immune, and glucose, emerged.
Effects of kinship correction on inflation of genetic interaction statistics in commonly used mouse populations
Anna L. Tyler,A. L. Tyler,B. El Kassaby,Georgi Kolishovski,Jake Emerson,Ann E. Wells,J. M. Mahoney,Gregory W. Carter +7 more
TL;DR: In this article, a survey of kinship effects on genetic interaction test statistics was performed on six commonly used mouse populations and the authors found that test statistic inflation varied across populations and was driven largely by linkage disequilibrium.
Transcriptome Analysis Reveals Organ-Specific Effects of 2-Deoxyglucose Treatment in Healthy Mice
Ann E. Wells,John J Wilson,Sarah E. Heuer,John D. Sears,Jian Wei,Raghav Pandey,Mauro W. Costa,Catherine C. Kaczorowski,Derry C. Roopenian,Chih Hao Chang,Gregory T. Carter +10 more
TL;DR: In this paper , the authors analyzed the transcriptional profiles of nine tissues from C57BL/6J mice treated with 2-deoxy-D-glucose (2DG) to understand how it modulates pathways systemically.