Ankush Aggarwal

TL;DR: This review provides a detailed summary of the computational biomechanical simulations used to inform and develop a higher level of understanding of BHV tissues and their failure modes and should serve as a tool not only to infer reliable and dependable prosthesis function, but also to instigate and facilitate the design of future bioprosthetic valves and clinically impact cardiology.

TL;DR: A review of recent research relevant to the TV within the scope of FTR provides future perspectives and extensions critical to enhancing the current understanding of the functioning and remodeling tricuspid valve in both the healthy and pathophysiological states.

TL;DR: It is determined that isolated valve interstitial cells from BAV leaflets show the same in vitro calcification pathways as those from the normal AV leaflets, suggesting the VICs are not intrinsically different when isolated, and that external features, such as abnormal microstructure and altered flow may be the primary contributors in the accelerated calcification experienced by BAV patients.

TL;DR: This work identifies four elastic moduli that are required to describe the two-dimensional elastic behavior of capsids and assigns functional relevance of the various moduli governing different deformation modes, including a mode primarily sensed in atomic force microscopy nanoindentation experiments.