Anke Busch
University of California, Irvine
15 Papers
66 Citations
Anke Busch is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Alternative splicing & RNA splicing. The author has an hindex of 13, co-authored 15 publications.
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Papers
Evolution of SR protein and hnRNP splicing regulatory factors.
Anke Busch,Klemens J. Hertel +1 more
TL;DR: It is argued that the increased presence of SR and hnRNP proteins promoted the evolution of alternative splicing through relaxation of the sequence requirements of splice junctions.
Position-dependent splicing activation and repression by SR and hnRNP proteins rely on common mechanisms
Steffen Erkelenz,William F. Mueller,Melanie S. Evans,Anke Busch,Katrin Schöneweis,Klemens J. Hertel,Heiner Schaal +6 more
TL;DR: It is shown that SR and hnRNP splicing factors exploit similar mechanisms to positively or negatively influence splice site selection, based on their binding location relative to regulated 5' splice sites.
The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma
Guido von Figura,Akihisa Fukuda,Nilotpal Roy,Muluye E. Liku,John P. Morris,Grace E. Kim,Holger A. Russ,Matthew A. Firpo,Sean J. Mulvihill,David W. Dawson,Jorge Ferrer,William F. Mueller,Anke Busch,Klemens J. Hertel,Matthias Hebrok +14 more
TL;DR: This study implicates Brg1 as a determinant of context-dependent Kras-driven pancreatic tumorigenesis and suggests that chromatin remodelling may underlie the development of distinct PDA subsets.
A splice donor mutation in NAA10 results in the dysregulation of the retinoic acid signalling pathway and causes Lenz microphthalmia syndrome
Taraneh Esmailpour,Hamidreza Riazifar,Linan Liu,Sandra Donkervoort,Sandra Donkervoort,Vincent Huang,Shreshtha Madaan,Bassem M. Shoucri,Anke Busch,Jie Wu,Alexander J. Towbin,Robert B Chadwick,Adolfo Sequeira,Marquis P. Vawter,Guoli Sun,Jennifer J. Johnston,Leslie G. Biesecker,Riki Kawaguchi,Hui Sun,Virginia Kimonis,Taosheng Huang +20 more
TL;DR: A mutation in the intron 7 splice donor site of the N-acetyltransferase NAA10 gene is identified that is the cause of Lenz microphthalmia syndrome in this family, likely through the dysregulation of the retinoic acid signalling pathway.
Dicer regulates differentiation and viability during mouse pancreatic cancer initiation.
John P. Morris,Renee L. Greer,Holger A. Russ,Guido von Figura,Grace E. Kim,Anke Busch,Jonghyeob Lee,Klemens J. Hertel,Seung K. Kim,Michael T. McManus,Matthias Hebrok +10 more
TL;DR: The data suggest that intact miRNA processing is involved in both constraining pro-tumorigenic changes in pancreatic differentiation as well as maintaining viability during PDA initiation.