Anja Köster
University of Göttingen
6 Papers
16 Citations
Anja Köster is an academic researcher from University of Göttingen. The author has contributed to research in topics: Mannose 6-phosphate receptor & Biology. The author has an hindex of 6, co-authored 6 publications.
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Papers
Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells.
Paul Saftig,Michal Hetman,Wolfgang W. Schmahl,K. Weber,L. Heine,H. Mossmann,Anja Köster,Barbara Hess,M Evers,K von Figura +9 more
TL;DR: It is suggested, that vital functions of cathepsin D are exerted by limited proteolysis of proteins regulating cell growth and/or tissue homeostasis, while its contribution to bulk proteolytic in lysosomes appears to be non‐critical.
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Mice deficient in lysosomal acid phosphatase develop lysosomal storage in the kidney and central nervous system.
Paul Saftig,Dieter Hartmann,Renate Lüllmann-Rauch,Joachim R. Wolff,M Evers,Anja Köster,Michal Hetman,Kurt von Figura,Christoph Peters +8 more
TL;DR: It is concluded that LAP has a unique function in only a subset of cells, where its deficiency causes the storage of a heterogeneously appearing material in lysosomes.
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Neonatal Lethality in Mice Deficient in XCE, a Novel Member of the Endothelin-converting Enzyme and Neutral Endopeptidase Family
Anja Schweizer,Olivier Valdenaire,Anja Köster,Yolande Lang,Georg Schmitt,Barbara Lenz,Horst Bluethmann,Jack Rohrer +7 more
TL;DR: The phenotype of the XCE-deficient mice together with the central nervous system-specific expression further suggest that XCE may play a vital role in the control of respiration.
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Mistargeting of Lysosomal Enzymes in Mr 46000 Mannose 6‐phosphate Receptor‐deficient Mice is Compensated by Carbohydrate‐specific Endocytotic Receptors
TL;DR: Results clearly show that lysosomal enzymes are mistargeted in MPR 46-deficient mice and that carbohydrate-specific endocytotic receptors are part of the mechanisms that compensate for the mistargeting of lysOSomal enzymes in M PR 46- deficient mice.
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Molecular cloning of the mouse 46-kDa mannose 6-phosphate receptor (MPR 46).
TL;DR: A cDNA clone for the mouse 46-kDa mannose 6-phosphate receptor (MPR 46) was isolated from an embryonic mouse cDNA library and shows an over-all amino-acid identity with the human receptor.
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