Anja Köster
Eli Lilly and Company
9 Papers
1 Citations
Anja Köster is an academic researcher from Eli Lilly and Company. The author has contributed to research in topics: Receptor & Biology. The author has an hindex of 8, co-authored 9 publications.
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Papers
Fibroblast Growth Factor-21 Improves Pancreatic β-Cell Function and Survival by Activation of Extracellular Signal–Regulated Kinase 1/2 and Akt Signaling Pathways
Wolf Wente,Alexander M. Efanov,Martin B. Brenner,Alexei Kharitonenkov,Anja Köster,George E. Sandusky,Sabine Sewing,Iris Treinies,Heike Zitzer,Jesper Gromada +9 more
TL;DR: Preservation of β-cell function and survival by FGF-21 may contribute to the beneficial effects of this protein on glucose homeostasis observed in diabetic animals.
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Transgenic angiopoietin-like (angptl)4 overexpression and targeted disruption of angptl4 and angptl3: regulation of triglyceride metabolism.
Anja Köster,Y. Bernice Chao,Marian Mosior,Amy M. Ford,Patricia Gonzalez-DeWhitt,John E. Hale,De-Shan Li,Yubin Qiu,Christopher C. Fraser,Derek D. Yang,Josef G. Heuer,S. Richard Jaskunas,Patrick I. Eacho +12 more
TL;DR: Angptl3 and Angptl4 function to regulate circulating triglyceride levels during different nutritional states and therefore play a role in lipid metabolism during feeding/fasting through differential inhibition of LPL.
Angptl4 Protects against Severe Proinflammatory Effects of Saturated Fat by Inhibiting Fatty Acid Uptake into Mesenteric Lymph Node Macrophages
Laeticia Lichtenstein,Frits Mattijssen,Nicole de Wit,Anastasia Georgiadi,Guido J. E. J. Hooiveld,Roelof van der Meer,Yin He,Ling Qi,Anja Köster,Jouke T. Tamsma,Nguan Soon Tan,Michael Müller,Sander Kersten,Sander Kersten +13 more
TL;DR: Induction of macrophage Angptl4 by fatty acids is part of a mechanism that serves to reduce postprandial lipid uptake from chyle into MLN-resident macrophages by inhibiting triglyceride hydrolysis, thereby preventing Macrophage activation and foam cell formation and protecting against progressive, uncontrolled saturated fat-induced inflammation.
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Absence of cocaine- and amphetamine-regulated transcript results in obesity in mice fed a high caloric diet.
Mark A. Asnicar,Dennis P. Smith,Derek D. Yang,Mark L. Heiman,Niles Fox,Yun-Fei Chen,Hansen M. Hsiung,Anja Köster +7 more
TL;DR: It is shown that CART deficiency predisposed mice to become obese on a calorically dense diet, and CART may not be a major anorectic signal compared with proopiomelanocortin or leptin in the regulation of energy homeostasis.
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Vasoactive intestinal polypeptide/pituitary adenylate cyclase-activating peptide receptor 2 deficiency in mice results in growth retardation and increased basal metabolic rate.
Mark A. Asnicar,Anja Köster,Mark L. Heiman,Frank C. Tinsley,Dennis P. Smith,Elizabeth Galbreath,Niles Fox,Yanfei Linda Ma,Werner F. Blum,Hansen M. Hsiung +9 more
TL;DR: The results suggest that VPAC2R plays an important role in growth, basal energy expenditure, and male reproductive functions.
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