Anja Bjølgerud
University of Oslo
8 Papers
75 Citations
Anja Bjølgerud is an academic researcher from University of Oslo. The author has contributed to research in topics: Single-nucleotide polymorphism & Cytotoxic T cell. The author has an hindex of 8, co-authored 8 publications. Previous affiliations of Anja Bjølgerud include Oslo University Hospital.
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Papers
Genome-wide DNA methylation profiles indicate CD8+ T cell hypermethylation in multiple sclerosis.
Steffan D. Bos,Christian M. Page,Bettina Kulle Andreassen,Emon Elboudwarej,Marte Wendel Gustavsen,Farren B.S. Briggs,Hong Quach,Ingvild Sørum Leikfoss,Anja Bjølgerud,Tone Berge,Hanne F. Harbo,Lisa F. Barcellos +11 more
TL;DR: Strong evidence for DNA hypermethylation of CD8+ T cells for MS patients was observed, indicating a role for DNA methylation in MS, and results suggest that largeDNA methylation differences for CpG-sites tested here do not contribute to MS susceptibility.
Oligoclonal band status in Scandinavian multiple sclerosis patients is associated with specific genetic risk alleles.
Inger-Lise Mero,Marte Wendel Gustavsen,Marte Wendel Gustavsen,Hanne Skarpodde Sæther,Siri Tennebø Flåm,Pål Berg-Hansen,Pål Berg-Hansen,Helle Bach Søndergaard,Poul Erik Hyldgaard Jensen,Tone Berge,Tone Berge,Anja Bjølgerud,Anja Bjølgerud,Aslaug Aamodt Muggerud,Aslaug Aamodt Muggerud,Jan Harald Aarseth,Kjell-Morten Myhr,Kjell-Morten Myhr,Elisabeth Gulowsen Celius,Finn Sellebjerg,Jan Hillert,Lars Alfredsson,Tomas Olsson,Annette Bang Oturai,Ingrid Kockum,Benedicte A. Lie,Bettina Kulle Andreassen,Hanne F. Harbo,Hanne F. Harbo +28 more
TL;DR: Both shared and distinct genetic risk for MS subtypes in the Scandinavian population defined by OCB status are confirmed and different clinical characteristics between the groups are indicated, suggesting differences in disease mechanisms between OCB negative and OCB positive MS with implications for patient management.
Environmental exposures and the risk of multiple sclerosis investigated in a Norwegian case–control study
Marte Wendel Gustavsen,Marte Wendel Gustavsen,Christian M. Page,Christian M. Page,Stine Marit Moen,Anja Bjølgerud,Anja Bjølgerud,Pål Berg-Hansen,Pål Berg-Hansen,Gro Owren Nygaard,Gro Owren Nygaard,Leiv Sandvik,Leiv Sandvik,Benedicte A. Lie,Elisabeth Gulowsen Celius,Hanne F. Harbo,Hanne F. Harbo +16 more
TL;DR: In this Norwegian MS case-control study of environmental exposures, it is replicated that infectious mononucleosis and smoking are associated with increased MS risk and a protective effect on MS of exposure to cats during childhood, in accordance with the hypothesis that risk of autoimmune diseases like MS may increase with high hygienic standard.
The multiple sclerosis susceptibility genes TAGAP and IL2RA are regulated by vitamin D in CD4+ T cells.
Tone Berge,Ingvild Sørum Leikfoss,Ingvild Sørum Leikfoss,Ina Skaara Brorson,Ina Skaara Brorson,Steffan D. Bos,Steffan D. Bos,Christian M. Page,Christian M. Page,Marte Wendel Gustavsen,Marte Wendel Gustavsen,Anja Bjølgerud,Anja Bjølgerud,Trygve Holmøy,Trygve Holmøy,Elisabeth Gulowsen Celius,Jan Damoiseaux,Joost Smolders,Hanne F. Harbo,Hanne F. Harbo,Anne Spurkland +20 more
TL;DR: In CD4+ T cells, in vitro vitamin D responsiveness of genes that contain an MS-associated single-nucleotide polymorphism (SNP) and with one or more vitamin D response elements in their regulatory regions are analyzed and IL2RA and TAGAP are identified as novel vitamin D target genes.
Multiple Sclerosis Risk Allele in CLEC16A Acts as an Expression Quantitative Trait Locus for CLEC16A and SOCS1 in CD4+ T Cells.
Ingvild Sørum Leikfoss,Ingvild Sørum Leikfoss,Pankaj Kumar Keshari,Pankaj Kumar Keshari,Marte Wendel Gustavsen,Marte Wendel Gustavsen,Anja Bjølgerud,Anja Bjølgerud,Ina Skaara Brorson,Ina Skaara Brorson,Elisabeth Gulowsen Celius,Elisabeth Gulowsen Celius,Anne Spurkland,Steffan D. Bos,Steffan D. Bos,Hanne F. Harbo,Hanne F. Harbo,Tone Berge +17 more
TL;DR: Pair-wise linear regression analysis revealed high correlation in gene expression in peripheral T cells of CIITA, DEXI, CLEC16A and SOCS1, implying a possible regulatory role for the multiple sclerosis-associated rs12927355 in CLEC 16A.