Angelo Gallo
University of Warwick
33 Papers
40 Citations
Angelo Gallo is an academic researcher from University of Warwick. The author has contributed to research in topics: Biology & Chemistry. The author has an hindex of 15, co-authored 27 publications. Previous affiliations of Angelo Gallo include University of Patras & University of Florence.
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Papers
The SARS-COV-2 Spike Protein Binds Sialic Acids, and Enables Rapid Detection in a Lateral Flow Point of Care Diagnostic Device
Alexander N. Baker,Sarah-Jane Richards,Collette S. Guy,Thomas R. Congdon,Muhammad Hasan,Alexander James Zwetsloot,Angelo Gallo,Józef R. Lewandowski,Phillip J. Stansfeld,Anne Straube,Marc Walker,Simona Chessa,Giulia Pergolizzi,Simone Dedola,Robert A. Field,Robert A. Field,Matthew I. Gibson +16 more
TL;DR: A glyconanoparticle platform is used to discover that N-acetyl neuraminic acid has affinity toward the SARS-COV-2 spike glycoprotein, demonstrating its glycan-binding function and the potential of this system as a low-cost detection platform.
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MIA40 is an oxidoreductase that catalyzes oxidative protein folding in mitochondria
Lucia Banci,Ivano Bertini,Chiara Cefaro,Simone Ciofi-Baffoni,Angelo Gallo,Manuele Martinelli,Dionisia P. Sideris,Dionisia P. Sideris,Nitsa Katrakili,Kostas Tokatlidis,Kostas Tokatlidis +10 more
TL;DR: MIA40 represents a thioredoxin-unrelated, minimal oxidoreductase, with a facile CPC redox active site that ensures its catalytic function in oxidative folding in mitochondria.
A novel intermembrane space-targeting signal docks cysteines onto Mia40 during mitochondrial oxidative folding.
Dionisia P. Sideris,Dionisia P. Sideris,Nikos Petrakis,Nikos Petrakis,Nitsa Katrakili,Despina Mikropoulou,Despina Mikropoulou,Angelo Gallo,Simone Ciofi-Baffoni,Lucia Banci,Ivano Bertini,Kostas Tokatlidis,Kostas Tokatlidis +12 more
TL;DR: A nine-residue intermembrane-targeting signal brings the active Cys of substrate proteins into contact with Mia40 oxidase for folding and import into mitochondria.
Functional reconstitution of mitochondrial Fe/S cluster synthesis on Isu1 reveals the involvement of ferredoxin
Holger Webert,Sven-Andreas Freibert,Angelo Gallo,Torsten Heidenreich,Uwe Linne,Stefan Amlacher,Ed Hurt,Ulrich Mühlenhoff,Lucia Banci,Roland Lill +9 more
TL;DR: The molecular function of the ferredoxin Yah1 and its human orthologue FDX2 in mitochondrial Fe/S cluster synthesis is defined and a pathway for electron flow from reduced ferred toxin to Isu1 is suggested.
Molecular chaperone function of Mia40 triggers consecutive induced folding steps of the substrate in mitochondrial protein import.
Lucia Banci,Ivano Bertini,Chiara Cefaro,Lucia Cenacchi,Simone Ciofi-Baffoni,Isabella C. Felli,Angelo Gallo,Leonardo Gonnelli,Enrico Luchinat,Dionisia P. Sideris,Kostas Tokatlidis +10 more
TL;DR: The Mia40-induced folding pathway provides a proof of principle for the general concept that internal targeting signals may operate as a folding nucleus upon compartment-specific activation.
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