Angela S. Laird
Macquarie University
40 Papers
107 Citations
Angela S. Laird is an academic researcher from Macquarie University. The author has contributed to research in topics: Zebrafish & Biology. The author has an hindex of 12, co-authored 34 publications. Previous affiliations of Angela S. Laird include University of New South Wales & Katholieke Universiteit Leuven.
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Papers
The Redox Activity of Protein Disulfide Isomerase Inhibits ALS Phenotypes in Cellular and Zebrafish Models
Sonam Parakh,Sonam Parakh,Sina Shadfar,Emma R. Perri,Emma R. Perri,Audrey Ragagnin,Claudia Vanesa Piattoni,Mariela B. Fogolín,Kristy C. Yuan,Hamideh Shahheydari,Emily K. Don,Collen J. Thomas,Yuning Hong,Marcelo A. Comini,Angela S. Laird,Damian M. Spencer,Julie D. Atkin,Julie D. Atkin +17 more
TL;DR: It is demonstrated that the redox function of protein disulfide isomerase (PDI) is protective against protein misfolding, cytoplasmic mislocalization of TDP-43, ER stress, ER-Golgi transport dysfunction, and apoptosis in neuronal cells expressing mutant T DP-43 or S OD1, and motor impairment in zebrafish expressing mutant SOD1.
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A simple and efficient protocol for the treatment of zebrafish colonies infected with parasitic nematodes.
TL;DR: A treatment protocol, which involved addition of fenbendazole, a drug used to treat nematode infections in cattle and sheep, to the fish feed, was devised, which effectively eradicated the parasite from a zebrafish colony.
25
Peripheral changes above and below injury level lead to prolonged vascular responses following high spinal cord injury.
TL;DR: Development of a widespread peripheral change producing prolonged vasoconstriction in response to PE, but not Meth, possibly due to reduced neuronal reuptake of PE after SCI is reported, the first study to report such a change in blood vessels not only below but also above injury level.
25
Effect of Treadmill Training on Autonomic Dysreflexia in Spinal Cord—Injured Rats
TL;DR: The results suggest that treadmill training exaggerated AD responses perhaps through a combination of enhanced vascular reactivity and central plasticity.
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Accelerated loss of hypoxia response in zebrafish with familial Alzheimer's disease-like mutation of presenilin 1.
Morgan Newman,Hani Moussavi Nik,Greg T. Sutherland,Nhi Hin,Woojin S. Kim,Woojin S. Kim,Glenda M. Halliday,Glenda M. Halliday,Suman Jayadev,Carole L. Smith,Angela S. Laird,Caitlin W. Lucas,Thaksaon Kittipassorn,Thaksaon Kittipassorn,Daniel J. Peet,Michael Lardelli +15 more
TL;DR: It is observed that age-dependent loss of HIF1 stabilisation under hypoxia is a phenomenon conserved across vertebrate classes and is associated with an apparent inability to upregulate glycolysis.
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