Angela L. Woods

TL;DR: Transcriptional profiling and/or mexX::lux promoter fusion analysis revealed that fmt and folD mutants were strongly upregulated for mexXY and another gene known to be required for upregulation of the pump, PA5471, which supports the notion that MexXY has a natural physiological function responding to impairment of ribosome function or protein synthesis and that fmt mutation (Fmt bypass) and fol D mutation generate the intracellular mex XY-inducing signal.

TL;DR: Argyrins are natural products with antibacterial activity against Gram-negative pathogens, such as Pseudomonas aeruginosa, Burkholderia multivorans, and Stenotrophomonas maltophilia, and it is shown that argyrin B targets elongation factor G (FusA) and activity against P. baumannii was inactive and resistance occurred at high frequency through loss of the sensitive FusA1.

TL;DR: The crystal structure of the LPS heptose kinase WaaP, which is essential for growth of P. aeruginosa, is solved and it is demonstrated that acyl-ACP is required for WAAP protein solubility and kinase function.

TL;DR: Pseudomonas aeruginosa Z61 showed that disruption of oprM increased susceptibility to pump substrate antibiotics, that inactivation of the inducible β-lactamase gene ampC contributed to β- lactam susceptibility, and that mutation of the lipopolysaccharide transporter gene lptE strongly altered the outer membrane permeability barrier, causing susceptibility to large antibiotics such as rifampin and also to β -lactams.