Angela D. Hyder-Wright
Liverpool School of Tropical Medicine
23 Papers
26 Citations
Angela D. Hyder-Wright is an academic researcher from Liverpool School of Tropical Medicine. The author has contributed to research in topics: Streptococcus pneumoniae & Medicine. The author has an hindex of 7, co-authored 17 publications. Previous affiliations of Angela D. Hyder-Wright include National Institute for Health Research & Royal Liverpool University Hospital.
Chat about Author
Papers
Innate and adaptive nasal mucosal immune responses following experimental human pneumococcal colonization.
Simon P. Jochems,Simon P. Jochems,Karin de Ruiter,Carla Solórzano,Astrid Voskamp,Elena Mitsi,Elissavet Nikolaou,Beatriz F. Carniel,Sherin Pojar,Esther L. German,Jesús Reiné,Alessandra Soares-Schanoski,Helen Hill,Rachel Robinson,Angela D. Hyder-Wright,Caroline M. Weight,Pascal F. Durrenberger,Robert S. Heyderman,Stephen B. Gordon,Stephen B. Gordon,Hermelijn H. Smits,Britta C. Urban,Jamie Rylance,Andrea M. Collins,Andrea M. Collins,Mark D. Wilkie,Lepa Lazarova,Samuel C. Leong,Samuel C. Leong,Maria Yazdanbakhsh,Daniela M. Ferreira +30 more
TL;DR: It is demonstrated that colonization affects mucosal and circulating B cell populations and implicate MAIT cells in the protection against pneumococcal colonization and with increased mucosal MAIT cell populations.
46
Nasal Pneumococcal Density Is Associated with Microaspiration and Heightened Human Alveolar Macrophage Responsiveness to Bacterial Pathogens
Elena Mitsi,Beatriz F. Carniel,Jesús Reiné,Jamie Rylance,Seher Zaidi,Alessandra Soares-Schanoski,Victoria Connor,Andrea M. Collins,Andreas Schlitzer,Elissavet Nikolaou,Carla Solórzano,Sherin Pojar,Helen Hill,Angela D. Hyder-Wright,Kondwani C. Jambo,Kondwani C. Jambo,Marco R. Oggioni,Megan De Ste Croix,Stephen B. Gordon,Simon P. Jochems,Simon P. Jochems,Daniela M. Ferreira +21 more
TL;DR: The findings demonstrate that nasal colonization with pneumococcus and microaspiration prime AM, leading to brisker responsiveness to both pneumococbus and unrelated bacterial pathogens, render them an attractive target for novel vaccines.
38
Pneumococcal Colonization in Healthy Adult Research Participants in the Conjugate Vaccine Era, United Kingdom, 2010–2017
Hugh Adler,Hugh Adler,Elissavet Nikolaou,Katherine A. Gould,Jason Hinds,Andrea M. Collins,Andrea M. Collins,Victoria Connor,Victoria Connor,Caz Hales,Caz Hales,Helen Hill,Helen Hill,Angela D. Hyder-Wright,Angela D. Hyder-Wright,Angela D. Hyder-Wright,Seher Zaidi,Seher Zaidi,Esther L. German,Jenna F. Gritzfeld,Elena Mitsi,Sherin Pojar,Stephen B. Gordon,Stephen B. Gordon,Adam P. Roberts,Jamie Rylance,Jamie Rylance,Daniela M. Ferreira +27 more
TL;DR: The outcomes of colonization screening in healthy adults who had volunteered to take part in clinical research who were nonsmokers without major comorbidities or contact with children aged <5 years are reported.
32
Experimental Human Pneumococcal Colonization in Older Adults Is Feasible and Safe, Not Immunogenic
Hugh Adler,Hugh Adler,Esther L. German,Elena Mitsi,Elissavet Nikolaou,Sherin Pojar,Caz Hales,Caz Hales,Rachel Robinson,Rachel Robinson,Victoria Connor,Victoria Connor,Helen Hill,Helen Hill,Angela D. Hyder-Wright,Angela D. Hyder-Wright,Lepa Lazarova,Lepa Lazarova,Catherine Lowe,Catherine Lowe,Emma L. Smith,Emma L. Smith,India Wheeler,India Wheeler,Seher Zaidi,Seher Zaidi,Simon P. Jochems,Dessi Loukov,Jesús Reiné,Carla Solorzano-Gonzalez,Polly De Gorguette D'Argoeuves,Tessa Jones,David Goldblatt,Tao Chen,Stephen Aston,Stephen Aston,Neil French,Neil French,Andrea M. Collins,Andrea M. Collins,Andrea M. Collins,Stephen B. Gordon,Stephen B. Gordon,Daniela M. Ferreira,Jamie Rylance,Jamie Rylance,Jamie Rylance +46 more
TL;DR: In older adults, experimental pneumococcal colonisation is feasible and safe, but demonstrates different immunological outcomes compared with younger adults in previous studies.
Respiratory mucosal immune memory to SARS-CoV-2 after infection and vaccination
Elena Mitsi,Mariana O Diniz,Jesús Reiné,Andrea M Collins,Ryan E Robinson,Angela D. Hyder-Wright,Madlen Farrar,K Liatsikos,Josh Hamilton,Onyia Onyema,Britta C Urban,Carla Solórzano,Sandra Belij-Rammerstorfer,Emma Sheehan,Teresa Lambe,Simon J. Draper,Daniela Weiskopf,Alessandro Sette,Mala K. Maini,Daniela M Ferreira +19 more
TL;DR: It is shown using bronchoalveolar lavage samples that donors with history of both infection and vaccination have more airway mucosal SARS-CoV-2 antibodies and memory B cells than those only vaccinated, supporting an argument for the need for vaccines targeting the airways.
26