Anette Wärnmark
Karolinska Institutet
11 Papers
109 Citations
Anette Wärnmark is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Nuclear receptor & Coactivator. The author has an hindex of 9, co-authored 11 publications. Previous affiliations of Anette Wärnmark include Södertörn University.
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Papers
Activation functions 1 and 2 of nuclear receptors: molecular strategies for transcriptional activation.
TL;DR: This review summarizes and discusses current knowledge regarding the molecular mechanisms of AF-1- and AF-2-mediated gene activation, focusing on AF- 1 andAF-2 conformation and coactivator binding.
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Interaction of Transcriptional Intermediary Factor 2 Nuclear Receptor Box Peptides with the Coactivator Binding Site of Estrogen Receptor Alpha.
Anette Wärnmark,Eckardt Treuter,Jan-Åke Gustafsson,Roderick E. Hubbard,Andrzej M. Brzozowski,Ashley C. W. Pike +5 more
TL;DR: Analysis of the binding properties of wild type NR box peptides, as well as mutant peptides designed to probe the Box B3 orientation, suggests that the box B3 peptide primarily adopts the “classical” LXXLL orientation in solution.
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The N-terminal regions of estrogen receptor alpha and beta are unstructured in vitro and show different TBP binding properties.
Anette Wärnmark,Anja Wikström,Anja Wikström,Anthony P. H. Wright,Anthony P. H. Wright,Jan-Åke Gustafsson,Torleif Härd +6 more
TL;DR: The results show that the intrinsically unstructured ER α-N interacts with TBP, and suggest that structural changes are induced in ERα-N upon TBP interaction, which supports models of TBP as a target protein for the N-terminal activation domain of ERα and suggests that target proteins can induce and/or stabilize ordered structure in N- terminal regions of nuclear receptors upon interaction.
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Competition between Thyroid Hormone Receptor-associated Protein (TRAP) 220 and Transcriptional Intermediary Factor (TIF) 2 for Binding to Nuclear Receptors IMPLICATIONS FOR THE RECRUITMENT OF TRAP AND p160 COACTIVATOR COMPLEXES
Eckardt Treuter,Lotta Johansson,Jane S. Thomsen,Anette Wärnmark,Jörg Leers,Markku Pelto-Huikko,Maria Sjöberg,Anthony P. H. Wright,Giannis Spyrou,Jan-Åke Gustafsson +9 more
TL;DR: Analysis of interaction and functional characteristics of TIF 2 and TRAP220 implies that competition between the NR-binding subunits of distinct coactivator complexes may act as a putative regulatory step in establishing either a sequential activation cascade or the formation of independent coactivators.
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Spontaneous mutations in the human CMV HLA class I homologue UL18 affect its binding to the inhibitory receptor LIR‐1/ILT2/CD85j
Cristina Cerboni,Adnane Achour,Anette Wärnmark,Mehrdad Mousavi-Jazi,Tatyana Sandalova,Mei Ling Hsu,David Cosman,Klas Kärre,Ennio Carbone +8 more
TL;DR: The results suggest the importance of two independent UL18 regions for LIR‐1 binding, one localized on the tip of the α3 domain, and another composed of two loops that emerge from the α1 domain.
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