Andy McPhee
Boston Children's Hospital
7 Papers
Andy McPhee is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Randomized controlled trial & Medicine. The author has an hindex of 4, co-authored 7 publications.
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Papers
Low-Dose Dexamethasone Facilitates Extubation Among Chronically Ventilator-Dependent Infants: A Multicenter, International, Randomized, Controlled Trial
TL;DR: Low-dose dexamethasone treatment after the first 1 week of life clearly facilitates extubation and shortens the duration of intubation among ventilator-dependent, very preterm/extremely low birth weight infants, without any obvious short-term complications.
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76 Low Dose Dexamethasone Facilitates Extubation in Ventilator-Dependent Infants - A Multicentre International Randomised Controlled Trial. The Dart Study Investigators
TL;DR: Low dose dexamethasone clearly facilitates extubation in ventilator-dependent very preterm/extremely low birthweight infants after the first week of life and there was little evidence for a reduction in the rate of oxygen dependency at 36 weeks.
•Journal Article
The DART study of low-dose dexamethasone therapy. Authors' reply
K J Rademaker,Floris Groenendaal,Frank van Bel,Linda S. de Vries,Cuno S.P.M. Uiterwaal,Lex W. Doyle,Peter G Davis,Colin J Morley,Andy McPhee,John B. Carlin +9 more
TL;DR: One of the objectives of the DART study was to determine the long-term effects of low-dose dexamethasone, and the study had to be stopped at an inclusion rate of <10% because of difficulties in recruitment.
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The DART Study of Low-Dose Dexamethasone Therapy: In Reply
TL;DR: The DART study did show differences even among the control groups, and the fact that some in the control group also received corticosteroids meant that the trial was less likely to find differences between the 2 groups.
Reopening the Debate on Corticosteroids: In Reply
TL;DR: A randomized, placebo-controlled trial of a 42-day tapering course of dexamethasone to reduce the duration of ventilator dependency in very low birth weight infants and the outcome of study participants at 1-year adjusted age is published.