Andy Lo
University of Auckland
14 Papers
14 Citations
Andy Lo is an academic researcher from University of Auckland. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 5, co-authored 9 publications.
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Papers
In silico investigation of the mechanisms underlying atrial fibrillation due to impaired Pitx2
Jieyun Bai,Jieyun Bai,Andy Lo,Patrick Gladding,Martin K. Stiles,Vadim V. Fedorov,Jichao Zhao +6 more
TL;DR: The study demonstrates that shortened action potential duration, slow conduction and triggered activity occur due to electrical and structural remodelling under Pitx2 deficiency conditions and suggests that flecainide has antiarrhythmic effects on AF due to impaired Pitx1 by preventing spontaneous calcium release and increasing wavelength.
PITX2 upregulation increases the risk of chronic atrial fibrillation in a dose-dependent manner by modulating I Ks and I CaL —insights from human atrial modelling
TL;DR: Electrical remodeling (IKs and ICaL) due to the PITX2 overexpression increases susceptibility to AF due to increased tissue vulnerability, abbreviated APD, shortened WL and altered CV, which, in combination, facilitate initiation and maintenance of spiral waves.
Proarrhythmia in the p.Met207Val PITX2c-Linked Familial Atrial Fibrillation-Insights From Modeling.
TL;DR: Electrical and structural remodeling arising from the PITX2c p.Met207Val mutation may increase atrial susceptibility to arrhythmia due to shortened APD, reduced CV and increased tissue vulnerability, which, in combination, facilitate initiation and maintenance of re-entrant excitation waves.
Afterdepolarizations and abnormal calcium handling in atrial myocytes with modulated SERCA uptake: a sensitivity analysis of calcium handling channels
TL;DR: For the first time, a modelling study reconciles different mechanisms of abnormal depolarizations in the setting of ‘lone’ AF, reduced TBX5, diabetes and heart failure, and may lead to more targeted treatment for these patients.
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Mechanisms underlying pro-arrhythmic abnormalities arising from Pitx2-induced electrical remodelling: an in silico intersubject variability study.
TL;DR: In this article, the authors identify Pitx2-induced changes in ionic currents that cause action potential (AP) shortening and lead to triggered activity in atrial fibrillation (AF) patients.