Andrew Tinker
National Institutes of Health
9 Papers
210 Citations
Andrew Tinker is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Ryanodine receptor & Conductance. The author has an hindex of 9, co-authored 9 publications. Previous affiliations of Andrew Tinker include Indiana University.
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Papers
How does ryanodine modify ion handling in the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel?
TL;DR: The findings indicate that the high affinity, essentially irreversible, interaction of ryanodine with the cardiac sarcoplasmic reticulum Ca(2+)-release channel produces a conformational alteration of the protein which results in modified ion handling.
Probing the structure of the conduction pathway of the sheep cardiac sarcoplasmic reticulum calcium-release channel with permeant and impermeant organic cations.
Andrew Tinker,Alan J. Williams +1 more
TL;DR: The conduction properties of a series of monovalent organic cations of varying size in the purified sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel are examined to provide additional information on structural features of the conduction pathway.
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Electrophysiological effects of ryanodine derivatives on the sheep cardiac sarcoplasmic reticulum calcium-release channel
Andrew Tinker,John L. Sutko,Luc Ruest,Pierre Deslongchamps,William Welch,Judith A. Airey,Koert Gerzon,Keshore R. Bidasee,Henry R. Besch,Alan J. Williams +9 more
TL;DR: The effects of a number of derivatives of ryanodine on K+ conduction in the Ca2+ release channel purified from sheep cardiac sarcoplasmic reticulum (SR) are examined, with the effect is irreversible within the lifetime of a single-channel experiment (up to 1 h).
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Cation conduction in the calcium release channel of the cardiac sarcoplasmic reticulum under physiological and pathophysiological conditions.
TL;DR: Variations in permeant ion concentration such as may occur in physiological and pathophysiological states may significantly affect the quantity of Ca2+ released from the cardiac sarcoplasmic reticulum.
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Charged local anesthetics block ionic conduction in the sheep cardiac sarcoplasmic reticulum calcium release channel
Andrew Tinker,Alan J. Williams +1 more
TL;DR: The substate block is interpreted physically as a form of partial occlusion in the vestibule of the conduction pathway giving a reduction in single-channel current by electrostatic means.
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