Andrew Sproul
Columbia University
21 Papers
87 Citations
Andrew Sproul is an academic researcher from Columbia University. The author has contributed to research in topics: Amyloid precursor protein & Induced pluripotent stem cell. The author has an hindex of 12, co-authored 21 publications. Previous affiliations of Andrew Sproul include Columbia University Medical Center & New York Stem Cell Foundation.
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Papers
Pluripotent stem cell-derived epithelium misidentified as brain microvascular endothelium requires ETS factors to acquire vascular fate.
Tyler M. Lu,Sean Houghton,Tarig Magdeldin,José Gabriel Barcia Durán,Andrew P. Minotti,Andrew P. Minotti,Amanda M. Snead,Andrew Sproul,Duc-Huy T. Nguyen,Jenny Xiang,Howard A. Fine,Zev Rosenwaks,Lorenz Studer,Shahin Rafii,Dritan Agalliu,David Redmond,Raphael Lis +16 more
TL;DR: In this paper, a comprehensive transcriptomic metaanalysis of previously published human pluripotent stem cells (hPSC)-derived cells validated by physiological assays was performed. And the authors demonstrated that iBMECs lack functional attributes of ECs since they are deficient in vascular lineage genes while expressing clusters of genes related to the neuroectodermal epithelial lineage.
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CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer’s PSEN2 N141I neurons
Maitane Ortiz-Virumbrales,Cesar L. Moreno,I. A. Kruglikov,Paula Marazuela,Andrew Sproul,Andrew Sproul,Samson T. Jacob,Matthew Zimmer,Daniel Paull,Bin Zhang,Eric E. Schadt,Michelle E. Ehrlich,Rudolph E. Tanzi,Ottavio Arancio,Scott Noggle,Sam Gandy +15 more
TL;DR: The genome editing data confirms the robust consistency of mutation-related changes in Aβ42/40 ratio while also showing a PSEN2-mutation-related alteration in electrophysiology.
CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage
Jichao Sun,Jared Carlson-Stevermer,Utpal Das,Minjie Shen,Marion Delenclos,Amanda M. Snead,So Yeon Koo,Lina Wang,Dianhua Qiao,Jonathan Loi,Andrew J. Petersen,Michael E. Stockton,Anita Bhattacharyya,Mathew V. Jones,Xinyu Zhao,Pamela J. McLean,Andrew Sproul,Krishanu Saha,Subhojit Roy +18 more
TL;DR: A CRISPR/Cas9-based strategy to selectively edit the C-terminus of APP and attenuate amyloid-β production, while upregulating neuroprotective α-cleavage is described.
The Alzheimer's disease-associated C99 fragment of APP regulates cellular cholesterol trafficking.
Jorge Montesinos,Marta Pera,Delfina Larrea,Cristina Guardia-Laguarta,Rishi R. Agrawal,Kevin R Velasco,Taekyung D Yun,Irina G Stavrovskaya,Yimeng Xu,So Yeon Koo,Amanda M. Snead,Andrew Sproul,Estela Area-Gomez +12 more
TL;DR: It is proposed that the 99‐aa C‐terminal fragment of APP (C99), when delivered to the ER for cleavage by γ‐secretase, acts as a lipid‐sensing peptide that forms regulatory DRMs in the ER, called mitochondria‐associated ER membranes (MAM).
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Siah1 Interacts with the Scaffold Protein POSH to Promote JNK Activation and Apoptosis
TL;DR: A “loop” mechanism in which the JNK pathway promotes SIAH1 stabilization and in which SIAh1 in turn activates the J NK pathway and, ultimately, contributes to cell death is revealed.
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