Andrew R. Houk
University of California, San Francisco
6 Papers
1 Citations
Andrew R. Houk is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Cell polarity & P70-S6 Kinase 1. The author has an hindex of 5, co-authored 6 publications. Previous affiliations of Andrew R. Houk include University of Iowa.
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Papers
The RNA silencing endonuclease Argonaute 2 mediates specific antiviral immunity in Drosophila melanogaster.
Ronald P. van Rij,Maria-Carla Saleh,Bassam Berry,Catherine K. Foo,Andrew R. Houk,Christophe Antoniewski,Raul Andino +6 more
TL;DR: The central catalytic component of the RNA-induced silencing complex (RISC), the nuclease Argonaute 2 (Ago-2), is essential for antiviral defense in adult Drosophila melanogaster.
Membrane tension maintains cell polarity by confining signals to the leading edge during neutrophil migration
Andrew R. Houk,Alexandra Jilkine,Cecile O. Mejean,Rostislav Boltyanskiy,Eric R. Dufresne,Sigurd Angenent,Steven J. Altschuler,Lani F. Wu,Orion D. Weiner +8 more
TL;DR: It is suggested that tension, rather than diffusible molecules generated or sequestered at the leading edge, is the dominant source of long-range inhibition that constrains the spread of the existing front and prevents the formation of secondary fronts.
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Compete Globally, Bud Locally
TL;DR: A synthetic biology approach is used to demonstrate that rapid competition for a soluble signaling component (Bem1) is essential to ensure a unique axis of polarity in budding yeast.
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A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition.
Neil E. Torbett,Antonio Luna-Moran,Zachary A. Knight,Andrew R. Houk,Mark M. Moasser,William A. Weiss,Kevan M. Shokat,David Stokoe +7 more
TL;DR: The data indicate that small-molecule PI3K isoform-selective inhibitors, alone or in suitable combinations, may be useful as breast cancer therapeutics, when used in appropriate genetic contexts.
Neutrophils Establish Rapid and Robust WAVE Complex Polarity in an Actin-Dependent Fashion
TL;DR: It is shown that spatially biased generation and selection of WAVE complex recruitment also occur in morphologically unpolarized neutrophils during development of their first protrusions, and several mechanisms limit WAVEcomplex recruitment during polarization and movement.