Andrew K. Sewell
Cardiff University
231 Papers
2.6K Citations
Andrew K. Sewell is an academic researcher from Cardiff University. The author has contributed to research in topics: T-cell receptor & T cell. The author has an hindex of 66, co-authored 222 publications. Previous affiliations of Andrew K. Sewell include University Hospital of Wales & John Radcliffe Hospital.
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Papers
Targeting T-Cell Receptor β-Constant Domain for Immunotherapy of T-Cell Malignancies
Paul Maciocia,Patrycja Wawrzyniecka,Brian Philip,Ida Ricciardelli,Ayse U. Akarca,Shimobi Onuoha,David K. Cole,Andrew K. Sewell,Karl S. Peggs,David C. Linch,Teresa Marafioti,Martin Pule +11 more
TL;DR: A novel approach to investigation and targeting of T-cell malignancies by distinguishing between two possible TCR β-chain constant regions is demonstrated and TRBC1: 2 ratios in viral-specific cells, suggesting that depletion of either subset would not remove viral immunity.
1
Peptide-Major Histocompatibility Complex Class I Tetramers with Enhanced Coreceptor Binding Properties Enable Visualization of Low Avidity Leukemia-Associated Antigen-Specific CD8 + T Cells.
J. Joseph Melenhorst,Phillip Scheinberg,Emma Gostick,Pratip K. Chattopadhyay,Anna Lissina,David K. Cole,Mario Roederer,Ethan Bornstein,Nancy F. Hensel,Daniel C. Douek,Andrew K. Sewell,A. John Barrett,David Price,David Price +13 more
TL;DR: A mutation in the heavy chain a2 domain of HLA-A*0201 is engineered that moderately enhances monomeric CD8 binding without impacting the TCR binding platform and provides the first validation of a novel approach to the physical detection of low avidity antigen-specific CD8 + T cell populations by flow cytometry.
1
Ligand Identification for Orphan MHC-Agnostic T-Cell Receptors by Whole Genome CRISPR-Cas9 Screening.
Michael D. Crowther,Mateusz Legut,Andrew K. Sewell +2 more
- 01 Jan 2022
TL;DR: An unbiased methodology for T-cell receptor ligand discovery that requires no a priori knowledge regarding the nature of the antigen is described.
Patent
Agents de liaison
Rodney E. Phillips,Peter Roderick Dunbar,Vincenzo Cerundolo,Andrew K. Sewell +3 more
- 04 Oct 2000
TL;DR: The authors concerne des complexes peptidiques de MHC ou des derives de ceux-ci, pouvant se lier, de maniere specifique, a des recepteurs de lymphocytes T a des temperatures beaucoup plus elevees qu'auparavant.