Andrew K. Sewell
Cardiff University
231 Papers
2.6K Citations
Andrew K. Sewell is an academic researcher from Cardiff University. The author has contributed to research in topics: T-cell receptor & T cell. The author has an hindex of 66, co-authored 222 publications. Previous affiliations of Andrew K. Sewell include University Hospital of Wales & John Radcliffe Hospital.
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Papers
Adoptive t-cell therapy for cancer in the United Kingdom: a review of activity for the British Society of Gene and Cell Therapy Annual Meeting 2015
David E. Gilham,John Anderson,John S. Bridgeman,Robert E. Hawkins,Mark A. Exley,Hans J. Stauss,John Maher,Martin Pule,Andrew K. Sewell,Gavin M. Bendle,Steven P. Lee,Waseem Qasim,Adrian J. Thrasher,Emma C. Morris +13 more
TL;DR: The diversity and expansion of clinical and preclinical studies within the United Kingdom while considering the background context of this work against new infrastructural developments and the requirements of nationalized healthcare delivery within the UK National Health Service are considered.
Polypropylene Sulfide Nanoparticle p24 Vaccine Promotes Dendritic Cell-Mediated Specific Immune Responses against HIV-1
Stephan M. Caucheteux,John Paul Mitchell,Matthew Owen Ivory,Sachiko Hirosue,Svetlana Hakobyan,Garry Dolton,Kristin Ladell,Kelly L. Miners,David Price,David Price,June Kan-Mitchell,Andrew K. Sewell,Frank O. Nestle,Arnaud Moris,Richard O. S. Karoo,James Caradoc Birchall,Melody A. Swartz,Jeffrey A. Hubbel,Fabien Blanchet,Vincent Piguet +19 more
TL;DR: An intradermal vaccine using HIV-1 p24 Gag peptide-conjugated polypropylene sulfide nanoparticle formulation did not accelerate the maturation of blood- or skin-derived subsets of dendritic cells, despite efficient uptake in the absence of adjuvant, and nanoparticle-based intrader mal antigen delivery may provide a new option in the global effort to develop an effective vaccine against HIV- 1.
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Molecular Rules Underpinning Enhanced Affinity Binding of Human T Cell Receptors Engineered for Immunotherapy.
Rory M. Crean,Bruce J. MacLachlan,Florian Madura,Thomas Whalley,Pierre J. Rizkallah,Christopher J. Holland,Catriona McMurran,Stephen Harper,Andrew James Godkin,Andrew K. Sewell,Christopher R. Pudney,Marc W. van der Kamp,David K. Cole +12 more
TL;DR: This study investigated the mechanisms underpinning human TCR affinity enhancement by comparing the crystal structures of engineered enhanced affinity TCRs with those of their wild-type progenitors, and performed molecular dynamics simulations to better understand the energetic mechanisms driving the affinity enhancements.
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Advances in T-cell epitope engineering
TL;DR: Curiously, this extensive T-cell cross-reactivity is strictly compartmentalized based on peptide length, in contrast to numerous other biological interactions such as antibodies, interleukins, lipoproteins, and structural membrane proteins which have half-lives measured in hours-to-days.
Generation of robust CD8+ T-cell responses against subdominant epitopes in conserved regions of HIV-1 by repertoire mining with mimotopes.
Keri L. Schaubert,David Price,David Price,Janelle R Salkowitz,Andrew K. Sewell,John Sidney,Tedi E. Asher,Sylvie E. Blondelle,Sharon Adams,Francesco M. Marincola,Aviva Joseph,Alessandro Sette,Daniel C. Douek,Velpandi Ayyavoo,Walter J. Storkus,Ming-Ying Leung,Hwee L. Ng,Otto O. Yang,Harris Goldstein,Darcy B. Wilson,June Kan-Mitchell,June Kan-Mitchell +21 more
TL;DR: Findings indicate that mimotopes can mobilize functional cross‐reactive clonotypes that are less readily recruited from the naïve T‐cell pool by the corresponding WT epitope, and could potentially override subdominance under certain circumstances and enhance vaccine‐induced responses to conserved but poorly immunogenic determinants within the HIV proteome.
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