Andrew J. Lees
University College London
917 Papers
5.7K Citations
Andrew J. Lees is an academic researcher from University College London. The author has contributed to research in topics: Parkinson's disease & Medicine. The author has an hindex of 140, co-authored 877 publications. Previous affiliations of Andrew J. Lees include Toronto Western Hospital & San Antonio River Authority.
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Papers
A clinical and pathological study of motor neurone disease on Guam.
Huw R. Morris,Safa Al-Sarraj,Claudia Schwab,Katrina Gwinn-Hardy,Jordi Pérez-Tur,Nicholas W. Wood,John Hardy,Andrew J. Lees,Patrick L. McGeer,S. E. Daniel,John C. Steele +10 more
TL;DR: Observations from this series suggest that pathologically classical MND on Guam may occur independently of neurofibrillary degeneration and the clinical features of PDC.
[123I]-FP-CIT-SPECT demonstrates dopaminergic deficit in orthostatic tremor.
Regina Katzenschlager,Durval C. Costa,Willibald Gerschlager,John D. O'Sullivan,J Zijlmans,S. Gacinovic,Walter Pirker,Adrian Wills,Kailash P. Bhatia,Andrew J. Lees,Peter Brown +10 more
TL;DR: The finding of a marked tracer uptake reduction on dopamine transporter SPECT supports a role of the dopaminergic system in orthostatic tremor, suggesting that other mechanisms must also be involved in the pathogenesis.
The significance of α-synuclein, amyloid-β and tau pathologies in Parkinson's disease progression and related dementia.
Yaroslau Compta,Laura Parkkinen,Peter A. Kempster,Marianna Selikhova,Tammaryn Lashley,Janice L. Holton,Andrew J. Lees,Tamas Revesz +7 more
TL;DR: The shared relevance of these pathologies in PD progression and dementia is in line with experimental data suggesting synergism between α-synuclein, tau and Aβ and with studies testing these proteins as disease biomarkers, hence favouring the eventual testing of therapeutic strategies targeting these proteins in PD.
Banking on brains: insights of brain donor relatives and friends from an experiential perspective
TL;DR: Key conclusions include the importance of integrated practice amongst relevant healthcare professionals as well as the need for supportive and informed communication and the value of the distinction between brain donation for research purposes and organ transplantation is questioned.
Tau-positive grains are constant in centenarians' hippocampus.
Chi-Tuan Pham,Rohan de Silva,Stéphane Haïk,Marc Verny,Annick Sachet,Bernard Forette,Andrew J. Lees,Jean-Jacques Hauw,Charles Duyckaerts +8 more
TL;DR: The influence of age on the prevalence of argyrophilic grain disease has been analyzed in the hippocampus from 29 centenarians, suggesting a maturation of the grains, and tau-positive grains have been underestimated in the very old population.