Andrew J. Ghio
United States Environmental Protection Agency
44 Papers
224 Citations
Andrew J. Ghio is an academic researcher from United States Environmental Protection Agency. The author has contributed to research in topics: Lung injury & Inflammation. The author has an hindex of 30, co-authored 44 publications. Previous affiliations of Andrew J. Ghio include Research Triangle Park & University of Texas at San Antonio.
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Papers
SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract.
Yixuan J. Hou,Kenichi Okuda,Caitlin E. Edwards,David R. Martinez,Takanori Asakura,Kenneth H. Dinnon,Takafumi Kato,Rhianna E. Lee,Boyd Yount,Teresa M. Mascenik,Gang Chen,Kenneth N. Olivier,Andrew J. Ghio,Longping V. Tse,Sarah R. Leist,Lisa E. Gralinski,Alexandra Schäfer,Hong Dang,Rodney C. Gilmore,Satoko Nakano,Ling Sun,M. Leslie Fulcher,Alessandra Livraghi-Butrico,Nathan I. Nicely,Mark J. Cameron,Cheryl M. Cameron,David J. Kelvin,David J. Kelvin,Aravinda M. de Silva,David M. Margolis,Alena J. Markmann,Luther A. Bartelt,Ross E. Zumwalt,Fernando J. Martinez,Steven P. Salvatore,Alain C. Borczuk,Purushothama Rao Tata,Vishwaraj Sontake,Adam J. Kimple,Ilona Jaspers,Wanda K. O'Neal,Scott H. Randell,Richard C. Boucher,Ralph S. Baric +43 more
TL;DR: The nasal susceptibility to SARS-CoV-2 with likely subsequent aspiration-mediated virus seeding to the lung in SARS/COVID-19 pathogenesis is highlighted and reagents provide a foundation for investigations into virus-host interactions in protective immunity, host susceptibility, and virus pathogenesis.
1.5K
Composition of air pollution particles and oxidative stress in cells, tissues, and living systems.
TL;DR: Oxidative stress following PM exposure initiates a series of cellular reactions that includes activation of kinase cascades and transcription factors and release of inflammatory mediators, which ultimately lead to cell injury or apoptosis.
513
Cytokine production by human airway epithelial cells after exposure to an air pollution particle is metal-dependent
TL;DR: It is demonstrated that metals present in ROFA may be responsible for production and release of inflammatory mediators by the respiratory tract epithelium and suggested that these mediators may contribute to the toxic effects of particulate air pollutants reported in epidemiology studies.
470
Inflammatory lung injury after bronchial instillation of air pollution particles.
Andrew J. Ghio,Robert B. Devlin +1 more
TL;DR: This is the first demonstration that pulmonary effects after experimental exposure of humans to PM can correlate with health outcomes observed in epidemiologic studies of the same material under normal exposure conditions and suggests that mass may not be the most appropriate metric to use in assessing health effects after PM exposure.
399
DMT1: A mammalian transporter for multiple metals
Michael D. Garrick,Kevin G. Dolan,Craig Horbinski,Andrew J. Ghio,Dennis Higgins,Michael Porubcin,Elizabeth G. Moore,Lucille N. Hainsworth,Jay N. Umbreit,Marcel E. Conrad,Lee Feng,Agnieska Lis,Jerome A. Roth,Stephen Singleton,Laura M. Garrick +14 more
TL;DR: Preliminary evidence using specific PCR primers and antibodies specific to the two isoforms indicates that -IRE mRNA and protein increase in response to exposure to metal in lungs and in a cell culture model; the +IRE form is unresponsive, indicating new role(s) for this multifunctional transporter.
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