Andrew G. Bowie
Trinity College, Dublin
134 Papers
497 Citations
Andrew G. Bowie is an academic researcher from Trinity College, Dublin. The author has contributed to research in topics: Innate immune system & Biology. The author has an hindex of 55, co-authored 123 publications. Previous affiliations of Andrew G. Bowie include University College Dublin.
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Papers
Recognition of herpesviruses by the innate immune system
TL;DR: Recent advances in the understanding of innate detection of herpesviruses are described, how this innate detection translates into anti-herpesvirus host defence, and how the viruses seek to evade this innate Detection to establish persistent infections.
Detection of Viral Infections by Innate Immunity.
TL;DR: Recent insights into the influence of PRR activation and inflammasomes on viral infections and what this means for the mammalian host are discussed.
309
The interleukin-1 receptor-associated kinases: critical regulators of innate immune signalling.
TL;DR: The potential targeting of these essential protein kinases therapeutically is discussed, given their critical role in IL-1/TLR signalling, and the IRAK family members have been implicated in certain disease models including human immunodeficiencies.
302
IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes
Jessica F. Almine,Craig A. J. O'Hare,Craig A. J. O'Hare,Gillian Dunphy,Gillian Dunphy,Ismar R. Haga,Rangeetha Jayaprakash Naik,Abdelmadjid Atrih,Dympna J. Connolly,Jordan Taylor,Ian R. Kelsall,Andrew G. Bowie,Philippa M. Beard,Philippa M. Beard,Leonie Unterholzner,Leonie Unterholzner +15 more
TL;DR: It is shown that interferon-γ inducible protein 16 (IFI16) cooperates with cGAS during DNA sensing in human keratinocytes, as both cGas and IFI16 are required for the full activation of an innate immune response to exogenous DNA and DNA viruses.
Viral immune modulators perturb the human molecular network by common and unique strategies
Andreas Pichlmair,Kumaran Kandasamy,Gualtiero Alvisi,Orla Mulhern,Roberto Sacco,Matthias Habjan,Marco Binder,Adrijana Stefanovic,Carol-Ann Eberle,Adriana Goncalves,Tilmann Bürckstümmer,André C. Müller,Astrid Fauster,Cathleen Holze,Kristina Lindsten,Stephen Goodbourn,Georg Kochs,Friedemann Weber,Friedemann Weber,Ralf Bartenschlager,Andrew G. Bowie,Keiryn L. Bennett,Jacques Colinge,Giulio Superti-Furga +23 more
TL;DR: It is shown that different viral perturbation patterns of the host molecular defence network can be deduced from a mass-spectrometry-based host-factor survey in a defined human cellular system by using 70 innate immune-modulating viORFs from 30 viral species.