Andrew G. Bowie
Trinity College, Dublin
134 Papers
497 Citations
Andrew G. Bowie is an academic researcher from Trinity College, Dublin. The author has contributed to research in topics: Innate immune system & Biology. The author has an hindex of 55, co-authored 123 publications. Previous affiliations of Andrew G. Bowie include University College Dublin.
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Papers
Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage.
Gillian Dunphy,Sinead M. Flannery,Jessica F. Almine,Dympna J. Connolly,Christina Paulus,Kasper L Jønsson,Martin R. Jakobsen,Michael Nevels,Andrew G. Bowie,Leonie Unterholzner +9 more
TL;DR: It is found that keratinocytes and other human cells mount an innate immune response within hours of etoposide-induced DNA damage, which involves the DNA sensing adaptor STING but is independent of the cytosolic DNA receptor cGAS.
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The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons
Elizabeth C. Carroll,Lei Jin,Andres Mori,Natalia Muñoz-Wolf,Ewa Oleszycka,Hannah B.T. Moran,Samira Mansouri,Craig P. McEntee,Eimear M Lambe,Else Marie Agger,Peter Andersen,Colm Cunningham,Paul J. Hertzog,Katherine A. Fitzgerald,Katherine A. Fitzgerald,Andrew G. Bowie,Ed C. Lavelle +16 more
TL;DR: It is demonstrated that a cationic polymer can engage the STING-cGAS pathway to trigger innate and adaptive immune responses, and is dependent on mitochondrial reactive oxygen species and the presence of cytoplasmic DNA.
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A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling
Andrew G. Bowie,Endre Kiss-Toth,Julian A. Symons,Geoffrey L. Smith,Steven K. Dower,Luke A. J. O'Neill +5 more
TL;DR: Two vaccinia virus ORFs are identified, termed A46R and A52R, that share amino acid sequence similarity with the Toll/IL-1 receptor (TIR) domain, a motif that defines the IL-1/Toll-like receptor (TLR) superfamily of receptors, which have a key role in innate immunity and inflammation.
Vaccinia virus protein A46R targets multiple Toll-like–interleukin-1 receptor adaptors and contributes to virulence
Julianne Stack,Ismar R. Haga,Martina Schröder,Nathan W. Bartlett,Geraldine Maloney,Patrick C. Reading,Katherine A. Fitzgerald,Geoffrey L. Smith,Andrew G. Bowie +8 more
TL;DR: The function of the vaccinia virus (VV) protein A46R is defined and it is shown it inhibits intracellular signalling by a range of Toll-like receptors (TLRs) and is functionally distinct from another described VV TLR inhibitor, A52R.
Vitamin C inhibits NF-kappa B activation by TNF via the activation of p38 mitogen-activated protein kinase.
TL;DR: It is reported that vitamin C inhibits the activation of NF-κB by multiple stimuli, including IL-1 and TNF in the endothelial cell line ECV304 and in primary HUVECs, and identifies p38 as an intracellular target for high dose vitamin C.
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