Andrew E. Libby
Georgetown University
23 Papers
28 Citations
Andrew E. Libby is an academic researcher from Georgetown University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 8, co-authored 14 publications. Previous affiliations of Andrew E. Libby include University of Colorado Denver & University of Haifa.
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Papers
Perilipin-2 Deletion Impairs Hepatic Lipid Accumulation by Interfering with Sterol Regulatory Element-binding Protein (SREBP) Activation and Altering the Hepatic Lipidome
TL;DR: The results identify PLIN2 as a determinant of global changes in the hepatic lipidome and suggest the hypothesis that these actions contribute to SREBP-regulated de novo lipogenesis involved in non-alcoholic fatty liver disease.
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Perilipin‐2 promotes obesity and progressive fatty liver disease in mice through mechanistically distinct hepatocyte and extra‐hepatocyte actions
David J. Orlicky,Andrew E. Libby,Elise S. Bales,Rachel H. McMahan,Jenifer Monks,Francisco G. La Rosa,James L. McManaman +6 more
TL;DR: Wild‐type mice and mice with hepatocyte‐specific or whole‐body deletions of perilipin‐2 (Plin2) were used to define hepatocyte and extra‐hepatocyte effects of altered cellular lipid storage on obesity and non‐alcoholic fatty liver disease (NAFLD) pathophysiology in a Western‐diet model of these disorders.
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Bile acid sequestration reverses liver injury and prevents progression of nonalcoholic steatohepatitis in Western diet–fed mice
Shogo Takahashi,Shogo Takahashi,Yuhuan Luo,Suman Ranjit,Suman Ranjit,Cen Xie,Andrew E. Libby,David J. Orlicky,Alexander Dvornikov,Xiaoxin X. Wang,Komuraiah Myakala,Bryce A. Jones,Kanchan Bhasin,Dong Wang,James L. McManaman,Kristopher W. Krausz,Enrico Gratton,Diana Ir,Charles E. Robertson,Daniel N. Frank,Frank J. Gonzalez,Moshe Levi +21 more
TL;DR: It is determined that treatment with the bile acid sequestrant sevelamer reversed the liver injury and prevented the progression of NASH, including steatosis, inflammation, and fibrosis in a Western diet–induced NASH mouse model.
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Advances in fluorescence microscopy techniques to study kidney function.
Suman Ranjit,Suman Ranjit,Luca Lanzano,Luca Lanzano,Andrew E. Libby,Enrico Gratton,Moshe Levi +6 more
TL;DR: How the development of cutting-edge technologies has enabled high spatiotemporal resolution of molecular interactions and processes, and how these approaches have aided the understanding of kidney dynamics is described.
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Exploring visceral and subcutaneous adipose tissue secretomes in human obesity: implications for metabolic disease.
Darcy E. Kahn,Emily Macias,Simona Zarini,A. Garfield,Karin A. Zemski Berry,Paul S. MacLean,Robert E. Gerszten,Andrew E. Libby,Claudia M. Solt,Jonathan Schoen,Bryan C. Bergman +10 more
TL;DR: The unique secretome of VAT has distinct and negative impact on hepatocyte and muscle insulin action and differences in immune/inflammatory response and extracellular matrix components are revealed.
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