Andrew Downes
University of Edinburgh
40 Papers
272 Citations
Andrew Downes is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Raman spectroscopy & Scanning tunneling microscope. The author has an hindex of 22, co-authored 40 publications. Previous affiliations of Andrew Downes include Centre national de la recherche scientifique & University of Cambridge.
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Papers
Raman Spectroscopy and Related Techniques in Biomedicine
Andrew Downes,Alistair Elfick +1 more
TL;DR: Coherent anti-Stokes Raman (CARS) microscopy and stimulated Raman loss (SRL) microscopeopy are orders of magnitude more efficient than Raman spectroscopy, and are able to acquire high quality chemically-specific images in seconds.
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Raman spectroscopy and CARS microscopy of stem cells and their derivatives.
TL;DR: Raman spectroscopy has revealed that DNA and RNA levels drop when a stem cell differentiates into other cell types, which is linked to a change in the relative sizes of the nucleus and cytoplasm.
Exploring the origin of tip-enhanced Raman scattering; preparation of efficient TERS probes with high yield
Mehdi Asghari-Khiavi,Bayden R. Wood,Pejman Hojati-Talemi,Andrew Downes,Donald McNaughton,Adam Mechler,Adam Mechler +6 more
TL;DR: In this paper, the aspect ratio of the tip can play a significant role in the efficiency of tip-enhanced Raman scattering (TERS) probes and the electrostatic field arising from the lightning-rod effect has a substantial role in observed TERS effect.
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Biomarker-free dielectrophoretic sorting of differentiating myoblast multipotent progenitor cells and their membrane analysis by Raman spectroscopy
TL;DR: It is demonstrated that the biomarker-free technique of dielectrophoresis (DEP) can be used to discriminate cells between stages of differentiation in the C2C12 myoblast multipotent mouse model and found that the fibroblast membranes contained a smaller proportion of saturated lipids than those of the myoblasts, suggesting that the membrane chemistry should also be taken into account.
Nonlinear optical microscopy for drug delivery monitoring and cancer tissue imaging
TL;DR: TPEF imaging showed that drugs are preferentially localized in the cytoplasm and the nuclear envelope in resistant cells and suggests the potential of multimodal nonlinear optical microscopy for early detection and diagnosis of cancer.
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