Andrew Asher Protter
Medivation
47 Papers
447 Citations
Andrew Asher Protter is an academic researcher from Medivation. The author has contributed to research in topics: Androgen receptor & Cancer. The author has an hindex of 18, co-authored 47 publications.
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Papers
Role of the androgen receptor in breast cancer and preclinical analysis of enzalutamide.
Dawn R. Cochrane,Sebastian Bernales,Britta M. Jacobsen,Diana M. Cittelly,Erin N. Howe,Nicholas C. D'Amato,Nicole S. Spoelstra,Susan M. Edgerton,Annie Jean,Javier Sanchez Guerrero,Francisco Gómez,Satyanarayana Medicherla,Iván E. Alfaro,Emma McCullagh,Paul Jedlicka,Kathleen C. Torkko,Ann D. Thor,Anthony D. Elias,Andrew Asher Protter,Jennifer K. Richer +19 more
TL;DR: This preclinical study supports the initiation of clinical studies evaluating enzalutamide for treatment of AR+ tumors regardless of ER status, since it blocks both androgen- and estrogen- mediated tumor growth.
Enzalutamide, an androgen receptor signaling inhibitor, induces tumor regression in a mouse model of castration-resistant prostate cancer.
Javier Sanchez Guerrero,Iván E. Alfaro,Francisco Gómez,Andrew Asher Protter,Sebastian Bernales +4 more
TL;DR: The effects of enzalutamide on AR signaling, AR‐dependent gene expression and cell apoptosis are investigated, including binding of androgens to AR, AR nuclear translocation and association of AR with DNA.
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Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model
John W. Steele,M. L. Lachenmayer,M. L. Lachenmayer,Shulin Ju,Aryeh Stock,J. Liken,Soong Ho Kim,Luz Delgado,Iván E. Alfaro,Sebastian Bernales,Giuseppe Verdile,Prashant Bharadwaj,Veer Bala Gupta,Renae Barr,A. Friss,Georgia Dolios,Rong Wang,Dagmar Ringe,Paul E. Fraser,David Westaway,P. St. George-Hyslop,Paul Szabo,Norman R. Relkin,Joseph D. Buxbaum,Charles G. Glabe,Charles G. Glabe,Andrew Asher Protter,Ralph N. Martins,Ralph N. Martins,Ralph N. Martins,Michelle E. Ehrlich,Gregory A. Petsko,Gregory A. Petsko,Zhenyu Yue,Sam Gandy,Sam Gandy +35 more
TL;DR: It is concluded that LAT possesses pro-autophagic properties in addition to the previously reported pro-neurogenic properties, both of which are potentially relevant to the treatment and/or prevention of neurodegenerative diseases.
118
Combination Therapy with a Second-Generation Androgen Receptor Antagonist and a Metastasis Vaccine Improves Survival in a Spontaneous Prostate Cancer Model
Andressa Ardiani,Benedetto Farsaci,Connie J. Rogers,Andrew Asher Protter,Zhimin Guo,Thomas H. King,David Apelian,James W. Hodge +7 more
TL;DR: The combination of enzalutamide and immunotherapy as a promising treatment strategy for castration-resistant prostate cancer treatment and the greatest survival benefit was seen in mice with advanced-stage prostate tumors.
81
Patent
Treatment of fibroproliferative disorders using tgf-beta inhibitors
Sarvajit Chakravarty,Sundeep Dugar,Linda S. Higgins,Ann M. Kapoun,David Y. Liu,George F. Schreiner,Andrew Asher Protter,Thomas-Toan Tran +7 more
- 16 May 2003
TL;DR: In this article, a method for treating fibroproliferative disorders associated with TGF-β signaling, by administering non-peptide small molecule inhibitors of TGF β specifically binding to the type I TGFβ receptor (TGFβ-R1), was proposed.
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