Andres Metspalu
University of Tartu
668 Papers
13.7K Citations
Andres Metspalu is an academic researcher from University of Tartu. The author has contributed to research in topics: Genome-wide association study & Biology. The author has an hindex of 144, co-authored 583 publications. Previous affiliations of Andres Metspalu include Estonian Biocentre & Asper Biotech.
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Papers
Evidence of Inbreeding Depression on Human Height
Ruth McQuillan,Niina Eklund,Niina Eklund,Nicola Pirastu,Maris Kuningas,Brian P. McEvoy,Tõnu Esko,Tanguy Corre,Gail Davies,Marika Kaakinen,Leo-Pekka Lyytikäinen,Kati Kristiansson,Kati Kristiansson,Aki S. Havulinna,Martin Gögele,Veronique Vitart,Albert Tenesa,Yurii S. Aulchenko,Caroline Hayward,Åsa Johansson,Mladen Boban,Sheila Ulivi,Antonietta Robino,Vesna Boraska,Wilmar Igl,Sarah H. Wild,Lina Zgaga,Lina Zgaga,Najaf Amin,Evropi Theodoratou,Ozren Polasek,Giorgia Girotto,Lorna M. Lopez,Cinzia Sala,Jari Lahti,Tiina Laatikainen,Inga Prokopenko,Inga Prokopenko,Mart Kals,Jorma Viikari,Jorma Viikari,Jian Yang,Anneli Pouta,Karol Estrada,Albert Hofman,Nelson B. Freimer,Nelson B. Freimer,Nicholas G. Martin,Mika Kähönen,Lili Milani,Markku Heliövaara,Erkki Vartiainen,Katri Räikkönen,Corrado Masciullo,John M. Starr,Andrew A. Hicks,Laura Esposito,Ivana Kolcic,Susan M. Farrington,Ben A. Oostra,Tatijana Zemunik,Harry Campbell,Mirna Kirin,Marina Pehlić,Flavio Faletra,David J. Porteous,Giorgio Pistis,Elisabeth Widen,Veikko Salomaa,Seppo Koskinen,Krista Fischer,Terho Lehtimäki,Andrew C. Heath,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Fernando Rivadeneira,Grant W. Montgomery,Henning Tiemeier,Henning Tiemeier,Anna-Liisa Hartikainen,Pamela A. F. Madden,Pio D'Adamo,Nicholas D. Hastie,Ulf Gyllensten,Alan F. Wright,Cornelia M. van Duijn,Malcolm G. Dunlop,Igor Rudan,Paolo Gasparini,Peter P. Pramstaller,Ian J. Deary,Daniela Toniolo,Johan G. Eriksson,Antti Jula,Olli T. Raitakari,Olli T. Raitakari,Andres Metspalu,Markus Perola,Markus Perola,Markus Perola,Marjo-Riitta Järvelin,André G. Uitterlinden,Peter M. Visscher,James F. Wilson +104 more
TL;DR: It is predicted that multiple, rare, recessive variants influence human height, and the methodology developed is generally applicable to heritable quantitative traits (QT), paving the way for an investigation into inbreeding effects, and therefore genetic architecture, on a range of QT of biomedical importance.
Genetic influence on social outcomes during and after the Soviet era in Estonia
Kaili Rimfeld,Eva Krapohl,Maciej Trzaskowski,Jonathan R. I. Coleman,Jonathan R. I. Coleman,Saskia Selzam,Philip S. Dale,Tõnu Esko,Andres Metspalu,Robert Plomin +9 more
TL;DR: An analysis of genetic influences on educational attainment and occupation in pre- versus post-Soviet-era Estonia shows that genetics has a much greater influence on social outcomes in a meritocratic society.
Large-Scale Genomic Analyses Link Reproductive Aging to Hypothalamic Signaling, Breast Cancer Susceptibility, and BRCA1-Mediated DNA Repair EDITORIAL COMMENT
Felix R. Day,Katherine S. Ruth,Deborah J. Thompson,Kathryn L. Lunetta,Kathryn L. Lunetta,Natalia Pervjakova,Daniel I. Chasman,Lisette Stolk,Hilary K. Finucane,Hilary K. Finucane,Patrick Sulem,Brendan Bulik-Sullivan,Brendan Bulik-Sullivan,Tõnu Esko,Andrew D. Johnson,Andrew D. Johnson,Cathy E. Elks,Nora Franceschini,Chunyan He,Elisabeth Altmaier,Jennifer A. Brody,Lude L. Franke,Jennifer E. Huffman,Jennifer E. Huffman,Jennifer E. Huffman,Margaux F. Keller,Patrick F. McArdle,Teresa Nutile,Eleonora Porcu,Eleonora Porcu,Antonietta Robino,Lynda M. Rose,Ursula M. Schick,Jennifer A. Smith,Alexander Teumer,Michela Traglia,Dragana Vuckovic,Jie Yao,Wei Zhao,Eva Albrecht,Najaf Amin,Tanguy Corre,Jouke-Jan Hottenga,Massimo Mangino,Massimo Mangino,Albert V. Smith,Toshiko Tanaka,Gonçalo R. Abecasis,Irene L. Andrulis,Irene L. Andrulis,Hoda Anton-Culver,Antonis C. Antoniou,Volker Arndt,Alice M. Arnold,Caterina Barbieri,Matthias W. Beckmann,Alicia Beeghly-Fadiel,Javier Benitez,Leslie Bernstein,Suzette J. Bielinski,Carl Blomqvist,Carl Blomqvist,Eric Boerwinkle,Eric Boerwinkle,Natalia Bogdanova,Stig E. Bojesen,Manjeet K. Bolla,Anne Lise Børresen-Dale,Thibaud Boutin,Hiltrud Brauch,Hiltrud Brauch,Hermann Brenner,Thomas Bruening,Barbara Burwinkel,Barbara Burwinkel,Archie Campbell,Harry Campbell,Stephen J. Chanock,J. Ross Chapman,Yii-Der Ida Chen,Georgia Chenevix-Trench,Fergus J. Couch,Andrea D. Coviello,Angela Cox,Kamila Czene,Hatef Darabi,Immaculata De Vivo,Ellen W. Demerath,Joe Dennis,Peter Devilee,Thilo Doerk,Isabel dos-Santos-Silva,Alison M. Dunning,John D. Eicher,John D. Eicher,Peter A. Fasching,Peter A. Fasching,Jessica D. Faul,Jonine D. Figueroa,Dieter Flesch-Janys,Ilaria Gandin,Melissa E. Garcia,Montserrat Garcia-Closas,Graham G. Giles,Giorgia Girotto,Mark S. Goldberg,Anna González-Neira,Mark O. Goodarzi,Megan L. Grove,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,Pascal Guénel,Pascal Guénel,Xiuqing Guo,Christopher A. Haiman,Per Hall,Ute Hamann,Brian E. Henderson,Lynne J. Hocking,Albert Hofman,Georg Homuth,Maartje J. Hooning,John L. Hopper,Frank B. Hu,Jinyan Huang,Keith Humphreys,David J. Hunter,Anna Jakubowska,Samuel E. Jones,Maria Kabisch,David Karasik,Julia A. Knight,Julia A. Knight,Ivana Kolcic,Charles Kooperberg,Veli-Matti Kosma,Jennifer Kriebel,Vessela N. Kristensen,Diether Lambrechts,Diether Lambrechts,Claudia Langenberg,Jingmei Li,Xin Li,Sara Lindstroem,Yongmei Liu,Jian'an Luan,Jan Lubinski,R Maegi,Arto Mannermaa,Judith Manz,Sara Margolin,Jonathan Marten,Nicholas G. Martin,Corrado Masciullo,Alfons Meindl,Kyriaki Michailidou,Evelin Mihailov,Lili Milani,Roger L. Milne,Martina Mueller-Nurasyid,Mike A. Nalls,Benjamin M. Neale,Benjamin M. Neale,Heli Nevanlinna,Heli Nevanlinna,Patrick Neven,Anne B. Newman,Børge G. Nordestgaard,Janet E. Olson,Sandosh Padmanabhan,Paolo Peterlongo,Ulrike Peters,Astrid Petersmann,Julian Peto,Paul D.P. Pharoah,Nicola Pirastu,Ailith Pirie,Giorgio Pistis,Giorgio Pistis,Ozren Polasek,David J. Porteous,Bruce M. Psaty,Katri Pylkaes,Paolo Radice,Leslie J. Raffel,Fernando Rivadeneira,Igor Rudan,Anja Rudolph,Daniela Ruggiero,Cinzia Sala,Serena Sanna,Elinor J. Sawyer,David Schlessinger,Marjanka K. Schmidt,Frank Schmidt,Rita K. Schmutzler,Minouk J. Schoemaker,Robert A. Scott,Caroline M. Seynaeve,Jacques Simard,Rossella Sorice,Melissa C. Southey,Doris Stoeckl,Konstantin Strauch,Anthony J. Swerdlow,Kent D. Taylor,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Amanda E. Toland,Ian Tomlinson,Thérèse Truong,Thérèse Truong,Laufey Tryggvadottir,Stephen T. Turner,Diego Vozzi,Qin Wang,Melissa Wellons,Gonneke Willemsen,James F. Wilson,Robert Winqvist,Bruce H. R. Wolffenbuttel,Alan F. Wright,Drakoulis Yannoukakos,Tatijana Zemunik,Wei Zheng,Marek Zygmunt,Sven Bergmann,Dorret I. Boomsma,Julie E. Buring,Luigi Ferrucci,Grant W. Montgomery,Vilmundur Gudnason,Tim D. Spector,Cornelia M. van Duijn,Behrooz Z. Alizadeh,Marina Ciullo,Laura Crisponi,Douglas F. Easton,Paolo Gasparini,Christian Gieger,Tamara B. Harris,Caroline Hayward,Sharon L.R. Kardia,Peter Kraft,Barbara McKnight,Andres Metspalu,Alanna C. Morrison,Alexander P. Reiner,Alexander P. Reiner,Paul M. Ridker,Jerome I. Rotter,Daniela Toniolo,André G. Uitterlinden,Sheila Ulivi,Henry Voelzke,Nicholas J. Wareham,David R. Weir,Laura M. Yerges-Armstrong,Alkes L. Price,Kari Stefansson,Kari Stefansson,Jenny A. Visser,Ken K. Ong,Jenny Chang-Claude,Joanne M. Murabito,Joanne M. Murabito,John R. B. Perry,Anna Murray +267 more
TL;DR: This is the first study to confirm the link between early and late menopause and breast cancer risk using genetic information and identifies both common and low-frequency coding variants associated with ANM.
The role of COX-2 and Nrf2/ARE in anti-inflammation and antioxidative stress: Aging and anti-aging.
TL;DR: It is hypothesize that COX-2 levels increase during the aging process because increasing levels of ROSs necessitate the involvement of COx-2-dependent EFOXs for anti-inflammation and Nrf2/ARE signaling for antioxidation, and proposed that CO X-2 may act as an intrinsic biological aging clock due to its role in balancing inflammatory and anti-inflammatory responses.
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Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus
Sébastien Jacquemont,Alexandre Reymond,Flore Zufferey,Louise Harewood,R. G. Walters,Zoltán Kutalik,Danielle Martinet,Yiping Shen,Armand Valsesia,Armand Valsesia,Noam D. Beckmann,Gudmar Thorleifsson,M. Belfiore,S. Bouquillon,Dominique Campion,Nicole de Leeuw,B. Vries,Tõnu Esko,Bridget A. Fernandez,Fernando Fernández-Aranda,José Manuel Fernández-Real,Mònica Gratacòs,Audrey Guilmatre,Juliane Hoyer,Marjo-Riitta Järvelin,Robert Booy,A. Kurg,C. Caignec,Katrin Männik,Orah S. Platt,Damien Sanlaville,M. Haelst,Sergio Gómez,Faida Walha,Bai-Lin Wu,Yongguo Yu,A. Aboura,Marie-Claude Addor,Yves Alembik,Stylianos E. Antonarakis,Benoît Arveiler,Magalie Barth,Nathalie Bednarek,Frédérique Béna,Sven Bergmann,M. Béri,Laura Bernardini,Bettina Blaumeiser,Dominique Bonneau,Armand Bottani,Odile Boute,H. Brunner,D. Cailley,Patrick Callier,Jean Chiesa,Jacqueline Chrast,Lachlan J. M. Coin,Charles Coutton,Jean-Marie Cuisset,J. Cuvellier,Albert David,B. Fréminville,Bruno Delobel,Marie-Ange Delrue,Bénédicte Demeer,Dominique Descamps,Gérard Didelot,Klaus Dieterich,Vittoria Disciglio,Martine Doco-Fenzy,Séverine Drunat,Bénédicte Duban-Bedu,Christèle Dubourg,Julia S. El-Sayed Moustafa,Paul Elliott,Brigitte H. W. Faas,Laurence Faivre,Anne Faudet,Florence Fellmann,A. Ferrarini,Richard Fisher,Elisabeth Flori,Lukas Forer,Dominique Gaillard,Marion Gérard,Christian Gieger,Stefania Gimelli,Giorgio Gimelli,Hans J. Grabe,Agnès Guichet,Olivier Guillin,Anna-Liisa Hartikainen,Delphine Héron,L. Hippolyte,Muriel Holder,Georg Homuth,Bertrand Isidor,Sylvie Jaillard,Zdenek Jaros,Susana Jiménez-Murcia,Géraldine Joly Helas,Philippe Jonveaux,Satu Kaksonen,Boris Keren,Anita Kloss-Brandstätter,Nine V A M Knoers,David A. Koolen,Peter M. Kroisel,Florian Kronenberg,Audrey Labalme,Emilie Landais,Elisabetta Lapi,Valérie Layet,Solenn Legallic,Bruno Leheup,Barbara Leube,Suzanne M E Lewis,Josette Lucas,Kay D. MacDermot,Páll Magnússon,Christian R. Marshall,M. Mathieu-Dramard,Mark I McCarthy,Thomas Meitinger,Maria Antonietta Mencarelli,Giuseppe Merla,Alexandre Moerman,Vincent Mooser,Fanny Morice-Picard,Mafalda Mucciolo,Matthias Nauck,Ndeye Coumba Ndiaye,Ann Nordgren,Laurent Pasquier,Florence Petit,Rolph Pfundt,G. Plessis,Evica Rajcan-Separovic,Gian Paolo Ramelli,Anita Rauch,Roberto Ravazzolo,André Reis,Alessandra Renieri,C. Richart,Janina S. Ried,Claudine Rieubland,Wendy Roberts,Katharina M. Roetzer,Caroline Rooryck,Massimiliano Rossi,Evald Saemundsen,Véronique Satre,Claudia Schurmann,Engilbert Sigurdsson,Dimitri J. Stavropoulos,Hreinn Stefansson,Carola Tengstrom,Unnur Thorsteinsdottir,F. J. Tinahones,Renaud Touraine,Louis Vallée,E. V. Binsbergen,N. Aa,Catherine Vincent-Delorme,Sophie Visvikis-Siest,Peter Vollenweider,H. Völzke,Anneke Vulto van Silfhout,Gérard Waeber,Carina Wallgren-pettersson,R. Witwicki,Simon Zwolinksi,J. Andrieux,Xavier Estivill,James F. Gusella,Ó. Gústafsson,Andres Metspalu,Stephen W. Scherer,Kari Stefansson,Alexandra I. F. Blakemore,Jacques S. Beckmann,P. Froguel +181 more
TL;DR: The reciprocal impact of these 16p11.2 copy-number variants indicates that severe obesity and being underweight could have mirror aetiologies, possibly through contrasting effects on energy balance.
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