Andres Metspalu
University of Tartu
668 Papers
13.7K Citations
Andres Metspalu is an academic researcher from University of Tartu. The author has contributed to research in topics: Genome-wide association study & Biology. The author has an hindex of 144, co-authored 583 publications. Previous affiliations of Andres Metspalu include Estonian Biocentre & Asper Biotech.
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Papers
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways
Lisette Stolk,John R. B. Perry,Daniel I. Chasman,Chunyan He,Massimo Mangino,Patrick Sulem,Maja Barbalić,Linda Broer,Enda M. Byrne,Florian Ernst,Tõnu Esko,Nora Franceschini,Daniel F. Gudbjartsson,Jouke-Jan Hottenga,P. Kraft,Patrick F. McArdle,Eleonora Porcu,So-Youn Shin,Albert V. Smith,S. van Wingerden,Guangju Zhai,Wei V. Zhuang,Eva Albrecht,Behrooz Z. Alizadeh,Thor Aspelund,Stefania Bandinelli,Lovorka Barać Lauc,Jacques S. Beckmann,Mladen Boban,Eric Boerwinkle,Frank J.M. Broekmans,Andrea Burri,Harry Campbell,Stephen J. Chanock,Constance Chen,Marilyn C. Cornelis,Tanguy Corre,Andrea D. Coviello,Pio D'Adamo,Gail Davies,U de Faire,E.J.C. de Geus,Ian J. Deary,George Dedoussis,Panagiotis Deloukas,Shah Ebrahim,G. Eiriksdottir,Valur Emilsson,Johan G. Eriksson,B. C. Fauser,Liana Ferreli,Luigi Ferrucci,Krista Fischer,Aaron R. Folsom,Melissa E. Garcia,Paolo Gasparini,Christian Gieger,Nicole L. Glazer,D. E. Grobbee,Per Hall,T. Haller,Susan E. Hankinson,M. Hass,Caroline Hayward,A. C. Heath,Albert Hofman,Erik Ingelsson,A. C. J. W. Janssens,Andrew D. Johnson,David Karasik,Sharon L.R. Kardia,Jules J. Keyzer,Douglas P. Kiel,Ivana Kolcic,Zoltán Kutalik,Jari Lahti,Sandra Lai,Triin Laisk,Joop S.E. Laven,Debbie A Lawlor,Jianjun Liu,Lorna M. Lopez,Yvonne V. Louwers,Patrik K. E. Magnusson,Mara Marongiu,Nicholas G. Martin,Irena Martinović Klarić,Corrado Masciullo,Barbara McKnight,S. E. Medland,David Melzer,Vincent Mooser,Pau Navarro,Anne B. Newman,Dale R. Nyholt,N. C. Onland-Moret,Aarno Palotie,Guillaume Paré,Alex Parker,N. L. Pedersen,P. H. M. Peeters,Giorgio Pistis,Andrew S. Plump,Ozren Polasek,Victor J M Pop,Bruce M. Psaty,Katri Räikkönen,Emil Rehnberg,Jerome I. Rotter,Igor Rudan,Cinzia Sala,Andres Salumets,Angelo Scuteri,AB Singleton,Jennifer A. Smith,Harold Snieder,Nicole Soranzo,Simon N. Stacey,John M. Starr,Maria G. Stathopoulou,Kathy Stirrups,Ronald P. Stolk,Unnur Styrkarsdottir,Yan V. Sun,Albert Tenesa,Barbara Thorand,Daniela Toniolo,Laufey Tryggvadottir,Kim Tsui,S. Ulivi,R. M. van Dam,Y. T. van der Schouw,C. H. van Gils,P. van Nierop,Jacqueline M. Vink,Peter M. Visscher,Marlies Voorhuis,G. Waeber,Henri Wallaschofski,H. E. Wichmann,Elisabeth Widen,C. J. Wijnands-van Gent,Gonneke Willemsen,James F. Wilson,Bruce H. R. Wolffenbuttel,A. F. Wright,Laura M. Yerges-Armstrong,Tatijana Zemunik,Lina Zgaga,M. C. Zillikens,Marek Zygmunt,T. L. Study,Alice M. Arnold,Dorret I. Boomsma,Julie E. Buring,Laura Crisponi,Ellen W. Demerath,Vilmundur Gudnason,Tamara B. Harris,Frank B. Hu,David J. Hunter,Lenore J. Launer,Andres Metspalu,Grant W. Montgomery,Ben A. Oostra,Paul M. Ridker,Serena Sanna,David Schlessinger,Tim D. Spector,Kari Stefansson,Elizabeth A. Streeten,Unnur Thorsteinsdottir,Manuela Uda,André G. Uitterlinden,C M van Duijn,Henry Völzke,Anna Murray,Joanne M. Murabito,Jenny A. Visser,Kathryn L. Lunetta +179 more
- 01 Jan 2012
TL;DR: A meta-analysis of genome-wide association studies in 38,968 women of European descent identified 13 loci newly associated with age at natural menopause, and candidate genes located at these newly associated loci include genes implicated in DNA repair and immune function.
155
Adiposity as a cause of cardiovascular disease: a Mendelian randomization study
Sara Hägg,Sara Hägg,Sara Hägg,Tove Fall,Tove Fall,Tove Fall,Alexander Ploner,Reedik Mägi,Krista Fischer,Harmen H.M. Draisma,Mart Kals,Paul S. de Vries,Abbas Dehghan,Sara M. Willems,Antti-Pekka Sarin,Antti-Pekka Sarin,Kati Kristiansson,Marja-Liisa Nuotio,Aki S. Havulinna,Renée F A G de Bruijn,M. Arfan Ikram,Maris Kuningas,Bruno H. Stricker,Oscar H. Franco,Beben Benyamin,Christian Gieger,Alistair S. Hall,Ville Huikari,Antti Jula,Marjo-Riitta Järvelin,Marika Kaakinen,Jaakko Kaprio,Michael Kobl,Massimo Mangino,Christopher P. Nelson,Aarno Palotie,Nilesh J. Samani,Tim D. Spector,David P. Strachan,Martin D. Tobin,John Whitfield,André G. Uitterlinden,Veikko Salomaa,Ann-Christine Syvänen,Ann-Christine Syvänen,Kari Kuulasmaa,Patrik K. E. Magnusson,Tõnu Esko,Albert Hofman,Eco J. C. de Geus,Lars Lind,Vilmantas Giedraitis,Markus Perola,Alun Evans,Jean Ferrières,Jarmo Virtamo,Frank Kee,David-Alexandre Trégouët,Dominique Arveiler,Philippe Amouyel,Francesco Gianfagna,Paolo Brambilla,Samuli Ripatti,Cornelia M. van Duijn,Andres Metspalu,Inga Prokopenko,Mark I. McCarthy,Nancy L. Pedersen,Erik Ingelsson +68 more
TL;DR: In this paper, the effect of body mass index (BMI) on risk of cardiovascular diseases was investigated using Mendelian randomization (MR) methods, and the results indicated a strong association between BMI and incident coronary heart disease (CHD), heart failure, and ischaemic stroke.
Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals
Esther H. Lips,Valerie Gaborieau,James McKay,Amelie Chabrier,Rayjean J. Hung,Rayjean J. Hung,Paolo Boffetta,Mia Hashibe,David Zaridze,Neonilia Szeszenia-Dabrowska,Jolanta Lissowska,Peter Rudnai,Eleonora Fabianova,Dana Mates,Vladimir Bencko,Lenka Foretova,Vladimir Janout,John K. Field,Triantafillos Liloglou,George Xinarianos,John R. McLaughlin,John R. McLaughlin,Geoffrey Liu,Frank Skorpen,Maiken Bratt Elvestad,Kristian Hveem,Lars J. Vatten,Epic Study,Simone Benhamou,Simone Benhamou,Pagona Lagiou,Ivana Holcatova,Franco Merletti,Kristina Kjærheim,Antonio Agudo,Xavier Castellsagué,Tatiana V. Macfarlane,Luigi Barzan,Cristina Canova,Ray Lowry,David I. Conway,Ariana Znaor,Claire M. Healy,Maria Paula Curado,Sergio Koifman,José Eluf-Neto,Elena Matos,Ana M. B. Menezes,Leticia Fernandez,Andres Metspalu,Simon Heath,Mark Lathrop,Mark Lathrop,Paul Brennan +53 more
TL;DR: This study confirms the strong association between 15q gene variants and LC and shows an independent association with smoking quantity, as well as an association with UADT cancers.
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A variant in MCF2L is associated with osteoarthritis.
Aaron G. Day-Williams,Lorraine Southam,Lorraine Southam,Kalliope Panoutsopoulou,Nigel W. Rayner,Tõnu Esko,Karol Estrada,Hafdis T. Helgadottir,Albert Hofman,Thorvaldur Ingvarsson,Thorvaldur Ingvarsson,Hakon Jonsson,Aime Keis,Kerkhof Hjm.,Gudmar Thorleifsson,Nigel K Arden,Nigel K Arden,Andrew Carr,Kay Chapman,Panagiotis Deloukas,John Loughlin,Andrew McCaskie,Andrew McCaskie,Ollier Wer.,Stuart H. Ralston,Tim D. Spector,Gillian A. Wallis,Jeremy Mark Wilkinson,Jeremy Mark Wilkinson,N Aslam,F Birell,F Birell,I Carluke,J Joseph,Ashok Rai,Mike R. Reed,K Walker,Sally Doherty,Ingileif Jonsdottir,Ingileif Jonsdottir,Rose A. Maciewicz,Kenneth Muir,Andres Metspalu,Fernando Rivadeneira,Kari Stefansson,Kari Stefansson,Unnur Styrkarsdottir,A.G. Uitterlinden,van Meurs Jbj.,Weiya Zhang,Ana M. Valdes,Michael Doherty,Eleftheria Zeggini +52 more
TL;DR: Through large-scale replication, a robust association with SNPs in MCF2L is established, and treatment with a humanized monoclonal antibody against NGF is associated with reduction in pain and improvement in function for knee OA patients.
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Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
Helen R. Warren,Evangelos Evangelou,Claudia P. Cabrera,He Gao,Meixia Ren,Borbala Mifsud,Ioanna Ntalla,Praveen Surendran,Chunyu Liu,James P. Cook,Aldi T. Kraja,Fotios Drenos,Marie Loh,Niek Verweij,Jonathan Marten,Ibrahim Karaman,Marcelo P. Segura Lepe,Paul F. O'Reilly,Joanne Knight,Harold Snieder,Norihiro Kato,Jiang He,E. Shyong Tai,M. Abdullah Said,David J. Porteous,Maris Alver,Neil Poulter,Martin Farrall,Ron T. Gansevoort,Sandosh Padmanabhan,Reedik Mägi,Alice Stanton,John M. C. Connell,Stephan J. L. Bakker,Andres Metspalu,Denis C. Shields,Simon Thom,Morris Brown,Peter S. Sever,Tõnu Esko,Caroline Hayward,Pim van der Harst,Danish Saleheen,Rajiv Chowdhury,John C. Chambers,Daniel I. Chasman,Aravinda Chakravarti,Christopher Newton-Cheh,Cecilia M. Lindgren,Daniel Levy,Jaspal S. Kooner,Bernard Keavney,Maciej Tomaszewski,Nilesh J. Samani,Joanna M. M. Howson,Martin D. Tobin,Patricia B. Munroe,Georg Ehret,Louise V. Wain,Michael R. Barnes,Joanna Tzoulaki,Mark J. Caulfield,Paul Elliott,Ahmad Vaez,Rick Jansen,Roby Joehanes,Peter J. van der Most,A. Mesut Erzurumluoglu,Paul O'Reilly,Lynda M. Rose,Germaine C. Verwoert,Jouke-Jan Hottenga,Rona J. Strawbridge,Dan E. Arking,Shih-Jen Hwang,Xiuqing Guo,Zoltán Kutalik,Stella Trompet,Nick Shrine,Alexander Teumer,Janina S. Ried,Joshua C. Bis,Albert V. Smith,Najaf Amin,Ilja M. Nolte,Leo-Pekka Lyytikäinen,Anubha Mahajan,Nicholas J. Wareham,Edith Hofer,Peter K. Joshi,Kati Kristiansson,Michela Traglia,Aki S. Havulinna,Anuj Goel,Mike A. Nalls,Siim Sõber,Dragana Vuckovic,Jian'an Luan,Fabiola Del Greco M,Kristin L. Ayers,Jaume Marrugat,Daniela Ruggiero,Lorna M. Lopez,Teemu J. Niiranen,Stefan Enroth,Anne U. Jackson,Christopher P. Nelson,Jennifer E. Huffman,Weihua Zhang,Ilaria Gandin,Sarah E. Harris,Tatijana Zemonik,Yingchang Lu,Nabi Shah,Martin H. de Borst,Massimo Mangino,Bram P. Prins,Archie Campbell,Ruifang Li-Gao,Ganesh Chauhan,Christopher Oldmeadow,Gonçalo R. Abecasis,Maryam Abedi,Caterina Barbieri,Chiara Batini,Tineka Blake,Michael Boehnke,Erwin P. Bottinger,Peter S. Braund,Marco Brumat,Harry Campbell,Massimiliano Cocca,Francis S. Collins,Heather J. Cordell,Jeffrey Damman,Gail Davies,Eco J. C. de Geus,Renée de Mutsert,Joris Deelen,Yusuf Demirkale,Alex S. F. Doney,Marcus Dörr,Teresa Ferreira,Mattias Frånberg,Vilmantas Giedraitis,Christian Gieger,Franco Giulianini,Alan J. Gow,Anders Hamsten,Tamara B. Harris,Albert Hofman,Elizabeth G. Holliday,Marjo-Riitta Järvelin,Åsa Johansson,Andrew D. Johnson,Pekka Jousilahti,Antti Jula,Mika Kähönen,Sekar Kathiresan,Kay-Tee Khaw,Ivana Kolcic,Seppo Koskinen,Claudia Langenberg,Marty Larson,Lenore J. Launer,Benjamin Lehne,David C. Liewald,Li Lin,Lars Lind,François Mach,Chrysovalanto Mamasoula,Cristina Menni,Yuri Milaneschi,Anna Morgan,Andrew D. Morris,Alanna C. Morrison,Peter J. Munson,Priyanka Nandakumar,Quang Tri Nguyen,Teresa Nutile,Albertine J. Oldehinkel,Ben A. Oostra,Elin Org,Aarno Palotie,Guillaume Paré,Alison Pattie,Brenda W.J.H. Penninx,Peter P. Pramstaller,Olli T. Raitakari,Kenneth Rice,Paul M. Ridker,Harriëtte Riese,Samuli Ripatti,Antonietta Robino,Jerome I. Rotter,Igor Rudan,Yasaman Saba,Aude Saint Pierre,Cinzia Sala,Antti-Pekka Sarin,Reinhold Schmidt,Rodney J. Scott,Marc A. Seelen,David S. Siscovick,Rossella Sorice,David J. Stott,Johan Sundström,Morris A. Swertz,Kent D. Taylor,Ioanna Tzoulaki,Christophe Tzourio,André G. Uitterlinden,Uwe Völker,Peter Vollenweider,Sarah H. Wild,Gonneke Willemsen,Alan F. Wright,Jie Yao,Sébastien Thériault,David Conen,Attia John,Stéphanie Debette,Dennis O. Mook-Kanamori,Eleftheria Zeggini,Tim D. Spector,Colin N. A. Palmer,Anne-Claire Vergnaud,Ruth J. F. Loos,Ozren Polasek,John M. Starr,Giorgia Girotto,C M Lindgren,Veronique Vitart,Jaakko Tuomilehto,Ulf Gyllensten,Paul Knekt,Ian J. Deary,Marina Ciullo,Roberto Elosua,Bernard Keavney,Andrew A. Hicks,Robert A. Scott,Paolo Gasparini,Maris Laan,Yongmei Liu,Hugh Watkins,Catharina A. Hartman,Veikko Salomaa,Daniela Toniolo,Markus Perola,James F. Wilson,Helena Schmidt,Jing Hua Zhao,Terho Lehtimäki,Cornelia M. van Duijn,Vilmundur Gudnason,Bruce M. Psaty,Annette Peters,Rainer Rettig,Alan James,J. Wouter Jukema,David P. Strachan,Walter Palmas,Erik Ingelsson,Dorret I. Boomsma,Oscar H. Franco,Murielle Bochud,Andrew P. Morris +267 more
- 01 Jan 2017
TL;DR: Results from genetic risk score models raise the possibility of a precision medicine approach through early lifestyle intervention to offset the impact of blood pressure–raising genetic variants on future cardiovascular disease risk.
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