Andreja Brozic
University of Ljubljana
9 Papers
55 Citations
Andreja Brozic is an academic researcher from University of Ljubljana. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 5, co-authored 6 publications.
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Papers
Multiple Delivery of siRNA against Endoglin into Murine Mammary Adenocarcinoma Prevents Angiogenesis and Delays Tumor Growth
Tanja Dolinsek,Bostjan Markelc,Gregor Sersa,Andrej Coer,Monika Stimac,Jaka Lavrencak,Andreja Brozic,Simona Kranjc,Maja Cemazar +8 more
TL;DR: The obtained results demonstrate that silencing of endoglin is a promising antiangiogenic therapy of tumors that could not be used as single treatment, but as an adjunct to the established cytotoxic treatment approaches.
Mechanisms of different response to ionizing irradiation in isogenic head and neck cancer cell lines
Vesna Todorovic,Ajda Prevc,Martina Niksic Zakelj,Monika Savarin,Andreja Brozic,Blaz Groselj,Primoz Strojan,Maja Cemazar,Gregor Sersa +8 more
TL;DR: It is concluded that the emergence of the radioresistance in the established radioresistant isogenic cells can be at least partially attributed to the enhanced DNA double-strand break repair, altered expression of DNA damage signalling and repair genes.
Synergistic effect of cisplatin chemotherapy combined with fractionated radiotherapy regimen in HPV-positive and HPV-negative experimental pharyngeal squamous cell carcinoma.
Simona Kranjc Brezar,Ajda Prevc,Martina Niksic Zakelj,Andreja Brozic,Maja Cemazar,Primoz Strojan,Gregor Sersa +6 more
TL;DR: It is suggested that HPV-positive tumors are more radiosensitive to fractionated regimen than to single-dose irradiation with concurrent cisplatin chemotherapy acting synergistically to irradiation.
Gene Electrotransfer of Canine Interleukin 12 into Canine Melanoma Cell Lines.
Ursa Lampreht,Urska Kamensek,Monika Stimac,Gregor Sersa,Natasa Tozon,Masa Bosnjak,Andreja Brozic,Geraldo Gileno de Sá Oliveira,Takayuki Nakagawa,Kohei Saeki,Maja Cemazar,Maja Cemazar +11 more
TL;DR: The obtained results showed that the newly constructed plasmids encoding canine IL-12 had similar or even higher expression capacity than the plasmid encoding human IL- 12, which represents a promising therapeutic plasmide for furtherIL-12 gene therapy in clinical studies for spontaneous canine tumors.
Dose-Modifying Factor of Radiation Therapy with Concurrent Cisplatin Treatment in HPV-Positive Squamous Cell Carcinoma: A Preclinical Study
Ajda Prevc,Simona Kranjc,Maja Cemazar,Vesna Todorovic,Bojana Zegura,Matjaz Novak,Metka Filipič,Margareta Strojan Flezar,Irena Srebotnik Kirbiš,Ana Rotter,Andreja Brozic,Martina Niksic Zakelj,Mario Poljak,Lea Hošnjak,Blaz Groselj,Primoz Strojan,Gregor Sersa +16 more
TL;DR: The dose-modifying factors for HPV-positive tumors with single-dose irradiation, with or without low radiosensitizing doses of cisplatin are determined and an increased radiosensitivity of HPV- positive SCC is determined, which might be a consequence ofHPV-induced changes in the cell cycle regulation and DNA damage response, leading to increased cell death.
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