Andrei Leonov
Max Planck Society
66 Papers
223 Citations
Andrei Leonov is an academic researcher from Max Planck Society. The author has contributed to research in topics: Chemistry & Protein aggregation. The author has an hindex of 21, co-authored 56 publications. Previous affiliations of Andrei Leonov include Ludwig Maximilian University of Munich & University of Göttingen.
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Papers
Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson’s disease
Jens Wagner,Sergey Ryazanov,Sergey Ryazanov,Andrei Leonov,Andrei Leonov,Johannes Levin,Song Shi,Felix Schmidt,Catharina Prix,Francisco J Pan-Montojo,Uwe Bertsch,Gerda Mitteregger-Kretzschmar,Markus Geissen,Martin Eiden,Fabienne Leidel,Thomas Hirschberger,Andreas A. Deeg,Julian J. Krauth,Wolfgang Zinth,Paul Tavan,Jens Pilger,Jens Pilger,Markus Zweckstetter,Markus Zweckstetter,Markus Zweckstetter,Tobias Frank,Mathias Bähr,Jochen H. Weishaupt,Manfred Uhr,Henning Urlaub,Henning Urlaub,Ulrike Teichmann,Matthias Samwer,Kai Bötzel,Martin H. Groschup,Hans A. Kretzschmar,Christian Griesinger,Christian Griesinger,Armin Giese +38 more
TL;DR: The findings suggest that pathological oligomers in neurodegenerative diseases share structural features, although the main protein component is disease-specific, indicating that compounds such as anle138b that modulate oligomer formation by targeting structure-dependent epitopes can have a broad spectrum of activity in the treatment of different protein aggregation diseases.
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The oligomer modulator anle138b inhibits disease progression in a Parkinson mouse model even with treatment started after disease onset
Johannes Levin,Felix Schmidt,Cathrin Boehm,Catharina Prix,Kai Bötzel,Sergey Ryazanov,Andrei Leonov,Christian Griesinger,Armin Giese +8 more
TL;DR: These findings support the belief that blocked formation and accumulation of asyn oligomers in the brain, reduced disease-associated motor deficits, and led to prolonged disease-free survival in parkinson’s disease.
Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson’s disease model
Michal Wegrzynowicz,Dana Bar-On,Laura Calo,Oleg Anichtchik,Mariangela Iovino,Jing Xia,Sergey Ryazanov,Sergey Ryazanov,Andrei Leonov,Andrei Leonov,Armin Giese,Jeffrey W. Dalley,Christian Griesinger,Christian Griesinger,Uri Ashery,Maria Grazia Spillantini +15 more
TL;DR: The MI2 mouse model recapitulates the progressive dopamine deficit observed in PD, showing that early synaptic dysfunction is associated to fine behavioral motor alterations, precedes dopaminergic axonal loss and neuronal death that become associated with a more consistent motor deficit upon reaching a certain threshold.
Cardiolipin promotes pore-forming activity of alpha-synuclein oligomers in mitochondrial membranes.
Stephanie Ghio,Angelique Camilleri,Mario Caruana,Viktoria Ruf,Felix Schmidt,Andrei Leonov,Sergey Ryazanov,Christian Griesinger,Ruben J. Cauchi,Frits Kamp,Armin Giese,Neville Vassallo +11 more
TL;DR: The formation of ion-permeable pores by αS oligomers in planar lipid bilayers reflecting the complex phospholipid composition of mitochondrial membranes was probed to preserve mitochondrial membrane integrity and alleviate mitochondrial dysfunction in PD.
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Shuttle DNP spectrometer with a two-center magnet
Alexander Krahn,Philip Lottmann,Thorsten Marquardsen,Andreas Tavernier,Maria-Teresa Türke,Marcel Reese,Andrei Leonov,Marina Bennati,Peter Hoefer,Frank Engelke,Christian Griesinger +10 more
TL;DR: Overhauser enhanced high resolution proton spectra of glucose and 2,2-dimethyl-2-silapentane-5-sulfonic acid sodium salt (DSS) in D(2)O, where the high resolution spectrum was acquired in the high-field position after polarizing the sample in the low-field.