Andreas Steinbrecher
University of Regensburg
41 Papers
60 Citations
Andreas Steinbrecher is an academic researcher from University of Regensburg. The author has contributed to research in topics: T cell & Medicine. The author has an hindex of 17, co-authored 39 publications.
Chat about Author
Papers
Inhibition of TGF-beta2 with AP 12009 in recurrent malignant gliomas: from preclinical to phase I/II studies.
Peter Hau,Piotr Jachimczak,Reimar Schlingensiepen,Frank J. Schulmeyer,Tanya Jauch,Andreas Steinbrecher,Alexander Brawanski,Martin Proescholdt,J. Schlaier,Johanna Buchroithner,Josef Pichler,Gabriele Wurm,Maximilian Mehdorn,Rainer Strege,Gerhard Schuierer,Victoria Villarrubia,Franz A. Fellner,Olav Jansen,Thorsten Straube,Virinder Nohria,Michael Goldbrunner,Mechthild Kunst,S. Schmaus,Gerhard Stauder,Ulrich Bogdahn,Karl-Hermann Schlingensiepen +25 more
TL;DR: Results implicate targeted TGF-beta2-suppression using AP 12009 as a promising novel approach for malignant gliomas and other highly aggressive, T GF-beta-2-overexpressing tumors.
217
Targeted tumor therapy with the TGF-β2 antisense compound AP 12009
Karl-Hermann Schlingensiepen,Reimar Schlingensiepen,Andreas Steinbrecher,Peter Hau,Ulrich Bogdahn,Birgit Fischer-Blass,Piotr Jachimczak +6 more
TL;DR: The results implicate targeted TGF-beta2 suppression as a promising therapeutic approach for malignant tumor therapy as well as safety and efficacy in clinical phase I/II open-label dose escalation studies in high-grade glioma patients.
187
Targeting Dipeptidyl Peptidase IV (CD26) Suppresses Autoimmune Encephalomyelitis and Up-Regulates TGF-β1 Secretion In Vivo
Andreas Steinbrecher,Dirk Reinhold,Laura Quigley,Ameer M Gado,Nancy Tresser,Leonid Izikson,Ilona Born,Jürgen Faust,Klaus Neubert,Roland Martin,Siegfried Ansorge,Stefan Brocke +11 more
TL;DR: The data suggest that DP IV inhibition represents a novel and specific therapeutic approach protecting from autoimmune disease by a mechanism that includes an active TGF-β1-mediated antiinflammatory effect at the site of pathology.
Myasthenic crisis demanding mechanical ventilation: A multicenter analysis of 250 cases.
Bernhard Neumann,Klemens Angstwurm,Philipp Mergenthaler,Siegfried Kohler,Silvia Schönenberger,Julian Bösel,Ursula Neumann,Amelie Vidal,Hagen B. Huttner,Stefan T. Gerner,Andrea Thieme,Andreas Steinbrecher,Juliane Dunkel,Christian Roth,Haucke Schneider,Eik Schimmel,Hannah Fuhrer,Christine Fahrendorf,Anke Alberty,Jan Zinke,Andreas Meisel,Christian Dohmen,Henning Stetefeld +22 more
TL;DR: Mortality and duration of myasthenic crisis remained comparable to previous reports despite higher age and a high disease burden in a German multicenter retrospective study.
119
RNOP-09: pegylated liposomal doxorubicine and prolonged temozolomide in addition to radiotherapy in newly diagnosed glioblastoma--a phase II study.
Christoph P. Beier,Christina Schmid,Thierry Gorlia,Christine Kleinletzenberger,Dagmar Beier,Oliver Grauer,Andreas Steinbrecher,Birgit Hirschmann,Alexander Brawanski,Christopher Dietmaier,Tanja Jauch-Worley,Oliver Kölbl,Torsten Pietsch,Martin Proescholdt,Petra Rümmele,Armin Muigg,G. Stockhammer,Monika E. Hegi,Ulrich Bogdahn,Peter Hau +19 more
TL;DR: Together, the investigated combination is tolerable and feasible and neither the addition of PEG-Dox nor the prolonged administration of Temozolomide resulted in a meaningful improvement of the patient's outcome as compared to the EORTC26981/NCIC-CE.3 data.
119