Andreas Rang
Charité
16 Papers
159 Citations
Andreas Rang is an academic researcher from Charité. The author has contributed to research in topics: Hantavirus & Virus. The author has an hindex of 12, co-authored 16 publications.
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Papers
Incoming RNA Virus Nucleocapsids Containing a 5′-Triphosphorylated Genome Activate RIG-I and Antiviral Signaling
Michaela Weber,Ali Gawanbacht,Matthias Habjan,Andreas Rang,Christoph Borner,Anna Mareike Schmidt,Sophie Veitinger,Ralf Jacob,Stephanie Devignot,Georg Kochs,Adolfo García-Sastre,Friedemann Weber,Friedemann Weber +12 more
TL;DR: It is shown that incoming viral nucleocapsids containing a 5'ppp dsRNA "panhandle" structure trigger antiviral signaling that commences with RIG-I, is mediated through the adaptor protein MAVS, and terminates with transcription factor IRF-3.
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Hantaan Virus Triggers TLR3-Dependent Innate Immune Responses
TL;DR: It is demonstrated that pathogenic Hantaan (HTNV) and putatively nonpathogenic Prospect Hill hantavirus (PHV) differentially activate innate responses in the established cell lines A549 and HuH7.5, suggesting that HTNV and PHV elicit different signaling cascades that converge via TRAF3.
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Dobrava-Belgrade Hantavirus from Germany Shows Receptor Usage and Innate Immunity Induction Consistent with the Pathogenicity of the Virus in Humans
Elena Popugaeva,Peter T. Witkowski,Mathias Schlegel,Rainer G. Ulrich,Brita Auste,Andreas Rang,Detlev H. Krüger,Boris Klempa,Boris Klempa +8 more
TL;DR: This study reveals novel data on Dobrava-Belgrade virus receptor usage and innate immunity induction in relationship to virus pathogenicity and underlines the potency of German DOBV strains to act as human pathogen.
Infection of in vivo differentiated human mast cells with hantaviruses
Sven Guhl,Renate Franke,Anika Schielke,Reimar Johne,Detlev H. Krüger,Magda Babina,Andreas Rang +6 more
TL;DR: It is demonstrated that mature mast cells are permissive to infection with hantaviruses, which might contribute to the development of vascular leakage syndrome.
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Genetic reassortment between high-virulent and low-virulent Dobrava - Belgrade virus strains
Sina Kirsanovs,Boris Klempa,Boris Klempa,Renate Franke,Min-Hi Lee,Günther Schönrich,Andreas Rang,Detlev H. Krüger +7 more
TL;DR: Efficient in vitro reassortment is found between members of two different genetic lineages of the Dobrava-Belgrade virus species, the weakly virulent DOBV-Aa and highly virulent dobV-Af.
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