Andreas M. Zeiher
Goethe University Frankfurt
606 Papers
7.5K Citations
Andreas M. Zeiher is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Medicine & Myocardial infarction. The author has an hindex of 129, co-authored 571 publications. Previous affiliations of Andreas M. Zeiher include University of Hamburg.
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Papers
Identification and Characterization of Hypoxia-Regulated Endothelial Circular RNA
Jes Niels Boeckel,Nicolas Jaé,Andreas W. Heumüller,Wei Chen,Reinier A. Boon,Konstantinos Stellos,Andreas M. Zeiher,David John,Shizuka Uchida,Stefanie Dimmeler +9 more
TL;DR: The data suggest that endothelial circRNAs are regulated by hypoxia and have biological functions, and the circRNA cZNF292 exhibits proangiogenic activities in vitro.
376
Circulating microRNAs: biomarkers or mediators of cardiovascular diseases?
TL;DR: The role of circulating miRs as a diagnostic or prognostic biomarker in cardiovascular disease is summarized and the mechanisms by which miRs are released and their putative function as long-distance communicators are discussed.
368
Antioxidative stress–associated genes in circulating progenitor cells: evidence for enhanced resistance against oxidative stress
Elisabeth Dernbach,Carmen Urbich,Ralf P. Brandes,Wolf K. Hofmann,Andreas M. Zeiher,Stefanie Dimmeler +5 more
TL;DR: EPCs reveal a higher expression of antioxidative enzymes and are exquisitely equipped to be protected against oxidative stress consistent with their progenitor cell character, and combined inhibition of these antioxidants increased ROS levels in EPCs and impaired EPC survival and migration.
366
Mitochondrial Telomerase Reverse Transcriptase Binds to and Protects Mitochondrial DNA and Function From Damage
Judith Haendeler,Stefan Dröse,Nicole Büchner,Sascha Jakob,Joachim Altschmied,Christine Goy,Ioakim Spyridopoulos,Andreas M. Zeiher,Ulrich Brandt,Stefanie Dimmeler +9 more
TL;DR: It is demonstrated that TERT is localized in the matrix of the mitochondria, which exerts a novel protective function by binding to mitochondrial DNA, increasing respiratory chain activity and protecting against oxidative stress–induced damage.
362
Nitric oxide activates telomerase and delays endothelial cell senescence
TL;DR: Examination of telomere length and the activity of telomerase during aging of human ECs in culture and the effect of nitric oxide elucidated demonstrate that telomersase inactivation precedes EC aging.
352