Andreas Karner
Johannes Kepler University of Linz
24 Papers
107 Citations
Andreas Karner is an academic researcher from Johannes Kepler University of Linz. The author has contributed to research in topics: Chemistry & Translocon. The author has an hindex of 8, co-authored 22 publications.
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Papers
DNA origami demonstrate the unique stimulatory power of single pMHCs as T cell antigens.
Joschka Hellmeier,René Platzer,Alexandra S. Eklund,Alexandra S. Eklund,Thomas Schlichthaerle,Thomas Schlichthaerle,Andreas Karner,Viktoria Motsch,Magdalena C. Schneider,Elke Kurz,Victor Bamieh,Mario Brameshuber,Johannes Preiner,Ralf Jungmann,Ralf Jungmann,Hannes Stockinger,Gerhard J. Schütz,Johannes B. Huppa,Eva Sevcsik +18 more
TL;DR: In this paper, a biomimetic interface based on laterally mobile functionalized DNA origami platforms was proposed for nanoscale control over ligand distances without interfering with the cell-intrinsic dynamics of receptor clustering.
84
High-Speed AFM Images of Thermal Motion Provide Stiffness Map of Interfacial Membrane Protein Moieties
Johannes Preiner,Andreas Horner,Andreas Karner,Nicole Ollinger,Christine Siligan,Peter Pohl,Peter Hinterdorfer +6 more
TL;DR: Stiffness maps of the main periplasmic loops of single reconstituted water channels revealed the spatial and temporal organization of loop-stabilizing intraproteinaceous H-bonds and salt bridges.
55
Tuning membrane protein mobility by confinement into nanodomains
Andreas Karner,Benedikt Nimmervoll,Birgit Plochberger,Enrico Klotzsch,Andreas Horner,Denis G. Knyazev,Roland Kuttner,Klemens Winkler,Lukas Winter,Christine Siligan,Nicole Ollinger,Peter Pohl,Johannes Preiner +12 more
TL;DR: It is shown that streptavidin crystals grown on mica-supported lipid bilayers can be used as porous supports for membranes containing biotinylated lipids and used to tune the lateral mobility of transmembrane proteins to any value within the dynamic range accessible to HS-AFM imaging.
35
Nanopharmacological Force Sensing to Reveal Allosteric Coupling in Transporter Binding Sites.
Rong Zhu,Doris Sinwel,Peter S. Hasenhuetl,Kusumika Saha,Vivek Kumar,Peng Zhang,Christian Rankl,Marion Holy,Sonja Sucic,Oliver Kudlacek,Andreas Karner,Walter Sandtner,Thomas Stockner,Hermann J. Gruber,Michael Freissmuth,Amy Hauck Newman,Harald H. Sitte,Peter Hinterdorfer +17 more
TL;DR: Novel tools for atomic force microscopy are designed that directly measure the interaction forces between the serotonin transporter (SERT) and the S- and R-enantiomers of citalopram on the single molecule level, providing physical evidence for the existence of two binding sites in SERT when accessed in a physiological context.
3D multiphoton lithography using biocompatible polymers with specific mechanical properties
Boris Buchroithner,Delara Hartmann,Sandra Mayr,Yoo Jin Oh,Dmitry Sivun,Andreas Karner,Bianca Buchegger,Thomas Griesser,Peter Hinterdorfer,Thomas A. Klar,Jaroslaw Jacak +10 more
- 17 Jun 2020
TL;DR: Two new, biocompatible polymers are shown, which can be 3D structured via multiphoton lithography, and their mechanical properties are determined through Atomic force microscopy analysis of structures with sub-micron feature sizes.