Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.

https://ir.uiowa.edu/cgi/viewcontent.cgi?article=1562&context=patents

Immunostimulatory nucleic acid molecules

Methods and apparatus are provided for selective surgical removal of tissue, e.g., for enlargement of diseased spinal structures, such as impinged lateral recesses and pathologically narrowed neural foramen. In some embodiments, a surgical tissue removal device includes a flexible elongate body that is adapted to conform with the target anatomy and a guidewire connector at the distal end region of the flexible elongate body configured to removably connect to the end of a guidewire so that the guidewire and flexible elongate body can be pulled distally. The body may have at least one blade edge, and the flexible elongate body may be a thin, flat, ribbon shaped flexible body that comprises a profile having a width that is substantially greater than a height.

Devices and methods for tissue access

Double-sided stretchable adhesive tapes are described for use in conventional applications, particularly including the mounting or joining of an object to another surface. An improvement lies within the ability to control the timing of the debonding of both surfaces so that one adhesive surface releases before the other. The earlier release can be either on the object side or the surface side, depending on the desired effect. The present invention is applicable to all stretchable tape constructions including the use of plastic backing materials and/or elastic backing materials and allows such an object to be removed without risking substantial snap-back of the adhesive tape or catapulting of the object. The aforementioned advantages can be achieved by a double-sided adhesive tape having a stretchable backing layer, plastic or elastic, and having a lower-adhesion or non-adhesive portion of one adhesive surface, so that a corresponding greater adhesion adhesive portion of the other side remains more aggressively adhered to a surface during stretch removal while the portion of the one adhesive surface is less aggressively adhered or completely released from its surface. A non-adhesive portion may be adhesive-free, or may be an adhesive layer portion which is rendered non-adhesive. A lower-adhesion portion may comprise a low adhesion material, i.e., a weaker adhesive, or may be rendered lower in adhesion by a treatment or coating.

Removable adhesive tape with controlled sequential release

A stretch releasing pressure sensitive adhesive tape includes a silicone pressure sensitive adhesive composition that exhibits a 180° peel strength on a glass substrate at 98 % relative humidity of at least about 5.47 N/dm and a non-tacky tab. A stretch releasing pressure sensitive adhesive tape includes a pressure sensitive adhesive composition having a modulus at 1 radian/second and -17 °C of no greater than about 1 x 107 Pa and a non-tacky tab.

Stretch releasing pressure sensitive adhesive tapes and articles

An article support adapted for adhering to a substrate is described. The article support preferably includes a base member, a stretch release adhesive tape adhered to that base member, and some mechanism for gripping the stretch release adhesive tape. These items are arranged so that when the base member is adhered to the substrate by the stretch release adhesive tape, the base member can be removed by pulling on the gripping means at an acute angle from the surface of the substrate. Gripping means which resist disassociation from the stretch release adhesive tape during the removal of the base from the substrate are disclosed, including handle types. The base member can be generic, suitable for attaching various types of support members via, for example, complimentary dovetail slides. In such cases, provision such as a latch can be made to temporarily lock the support member to the base member. The article support can be provided so that when the support member is removed from the base member, the gripping mechanism engages the support member to automatically stretch the tape and remove the base member from the substrate.

Article support using stretch releasing adhesives

Verwendung eines Streifens einer Klebefolie für wiederlösbare Verklebung

Adhesive film strip for a temporary bond which can be detached without residue and without damage by pulling in the direction of the bond plane, having a layer structure comprising an elastic backing layer which is provided on one or both sides with an adhesive layer, characterized in that both the backing layer and the adhesive layer(s) comprise styrene block copolymers as base polymers, blended with tackifier resins which are compatible with the elastomer block of the styrene block copolymers used.

Adhesive film strip

Doppelseitiges Klebeband und seine Verwendung

A contact adhesive composition based on styrene block copolymers containing at least one ethylene/butylene or ethylene/propylene block, a second polystyrene block of radial, star-shaped, or linear structure, and an adhesive resin miscible with elastomer phases. A contact adhesive composition based on styrene block copolymers contains: (a) a first styrene block copolymer containing at least one ethylene/butylenes- or ethylene/propylene block, at least two spatially separated, preferably linked to such a polystyrene block so that one or more polymer blocks is based on 1,3-unsaturated dienes, where the polystyrene block content is 12.5-37.5 wt.% and the content of polymer blocks based on 1,3-unsaturated dienes is 15-55 wt.%; (b) a second polystyrene block of radial, star-shaped or linear structure containing at least one ethylene/butylenes- or ethylene/propylene block, and at least two spatially separated polystyrene blocks, preferably linked to the ethylene/butylenes or ethylene/propylene blocks, where the polystyrene block content is 10-25 wt.%; and (c) an adhesive resin mixed with elastomer phases formed from (a) and (b).

Contact adhesive composition based on ethylene/butylenes or ethylene/propylene block copolymers, useful for production of adhesive film strips which can be peeled off without residues and without destruction

Redetachable, self-adhesive device having a plate, the sides and/or front side of which have fastening means, if appropriate, and the rear side of which has a strip of an adhesive film which is adhesive on both sides and is adhesively attached in such a way that one end of the adhesive film protrudes beyond the plate as a grip, the adhesive film being of such a kind that the adhesive bond achieved with it can be released again by pulling in the direction of the bonding plane, stretching the strip, characterized in that the rear side of the plate (1) has laterally alongside the adhesively attached adhesive film (5) spacers (3A, 3B), the height of which is less than the thickness of the adhesive film (5).

Redetachable, self-adhesive device

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