Andreas Hofmann
7 Papers
2 Citations
Andreas Hofmann is an academic researcher. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 2, co-authored 3 publications.
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Papers
DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance
Martin Schröder,Martin Renatus,Xiaoyou Liang,Fabian Meili,Thomas Zoller,Sandrine Ferrand,François Gauter,Xiaoyan Li,Frederic Sigoillot,Scott Gleim,Therese-Marie Stachyra,Jason R Thomas,Damien Begue,Maryam Khoshouei,Peggy Lefeuvre,Rita Andraos-Rey,BoYee Chung,Renate Ma,Benika J. Pinch,Andreas Hofmann,Markus Schirle,Niko Schmiedeberg,Patricia Imbach,Delphine Gorses,Keith Calkins,Beatrice Bauer-Probst,Magdalena Maschlej,Matt Niederst,Robert Maher,Martin Henault,John Alford,Erik Ahrne,Luca Tordella,Greg Hollingworth,Nicolas H. Thomä,Anna Vulpetti,Thomas Radimerski,Philipp Holzer,Seth Carbonneau,Claudio R. Thoma +39 more
TL;DR: Researchers developed DCAF1-based PROTACs that target clinically validated proteins, overcoming resistance to existing degraders by utilizing a novel E3 ligase receptor, DCAF1, and demonstrating efficacy in cells with acquired and intrinsic resistance.
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Disease association of anti-CEL autoantibodies in hidradenitis suppurativa.
Giulio Macchiarella,Vanessa Cornacchione,Celine Cojean,Julia Christina Riker,Yichen Wang,Hélène Té,Melanie Ceci,Johann E. Gudjonsson,Swann Gaulis,Jean Francois Goetschy,Audrey Wollschlegel,S. Gass,Sofia Oetliker-Contin,Barbara Wettstein-Ling,Dirk J. Schaefer,Pascale Meschberger,Roland de Roche,Rik Osinga,Grazyna Wieczorek,U Naumann,Joachim Lehmann,Anna Schubart,Andreas Hofmann,Lukas Roth,Edwin Florencia,Christian Loesche,Elisabetta Traggiai,Alexandre Avrameas,Errol P. Prens,Till A. Röhn,Ben Roediger +30 more
TL;DR: In this article , the authors identify a high prevalence of IgM, IgG, and IgA antibodies directed against Nε-carboxyethyl lysine (CEL), a methylglyoxal-induced advanced glycation end-product, in the sera of patients with Hidradenitis suppurativa.
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Reinstating targeted protein degradation with DCAF1 PROTACs in CRBN PROTAC resistant settings
Martin Schröder,Martin Renatus,Xiaoyou Liang,Fabian Meili,Thomas Zoller,Sandrine Ferrand,François Gauter,Frederic Sigoillot,Scott Gleim,Jason R. Thomas,Damien Begue,Rita Andraos-Rey,BoYee Chung,Seth Carbonneau,Benika J. Pinch,Andreas Hofmann,Markus Schirle,Patricia Imbach,Delphine Gorses,Keith Calkins,Beatrice Bauer-Probst,Matthew J. Niederst,Rob Maher,Martin Henault,John Alford,Erik Ahrne,Gregory John Hollingworth,Nicolas H. Thomä,Anna Vulpetti,Thomas Radimerski,Philipp Holzer,Claudio R. Thoma +31 more
TL;DR: In this article , the essential E3 ligase receptor DCAF1 can be harnessed for targeted protein degradation (TPD) utilizing a potent, non-covalent DCAF 1 binder.
A novel HERC4-dependent glue degrader targeting STING
Merve Mutlu,Isabel Schmidt,Andrew I. Morrison,H. Goretzki,Felix Freuler,Damien Begue,Nicolas Pythoud,Erik Ahrne,Sandra Kapps,Susan Roest,Debora Bonenfant,Delphine Jeanpierre,Thi-Thanh Thao Tran,Rob Maher,Shaojian An,Amandine Rietsch,Florian Nigsch,Andreas Hofmann,John S. Reece-Hoyes,Christian N. Parker,Danilo Guerini +20 more
TL;DR: In this paper , the authors identified AK59 as a molecular glue degrader for STING and showed that the compound-induced degradation of STING by AK59 is compromised by the loss of HECT and RLD domain containing E3 ubiquitin protein ligase 4 (HERC4), ubiquitIN-like modifier activating enzyme 5 (UBA5) and UBA6, while HERC4 is the main E3 ligase for the observed degradation mechanism.
A cereblon (CRBN) molecular glue degrader of NIMA-related kinase 7 (NEK7) reveals a context-dependent role in NLRP3 inflammasome activation
Aude Sylvain,N. Stoehr,Fupeng Ma,Artiom Cernijenko,Martin Schröder,Melanie Vogelsanger,Michel Schoenboerner,Ashley Burke,Rao Pasupuleti,Jonathan M. Solomon,Joshiawa Lanair James Paulk,Lei Xu,Janet Dawson,Damien Begue,Peggy Lefeuvre,Erik Ahrne,Andreas Hofmann,Callum J. Dickson,Philip Arabin,Alfred Zimmerlin,Michael Kiffe,Mirjam Froehlicher,Theresa Boersig,Azeddine Elhajouji,Murielle Brichet,Sue Menon,Shanming Liu,Matthias Mueller,Charles Wartchow,James Lin,Yamel Cardona Gloria,Sabine Dickhöfer,Alex Weber,Tatjana Welzel,Jasmin Kuemmerle-Deschner,Christopher J. Farady,Robert Pulz,Frédéric Bornancin,Dennis L. Buckley,Zuni I. Bassi +39 more
TL;DR: Researchers identified NK7-902, a cereblon molecular glue degrader of NEK7, which selectively degrades NEK7 in human and mouse cells, but its impact on NLRP3 inflammasome activation varies across species and donors, suggesting a context-dependent role for NEK7 in inflammation.