Andreas Gast
German Cancer Research Center
20 Papers
299 Citations
Andreas Gast is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Haplotype & Single-nucleotide polymorphism. The author has an hindex of 14, co-authored 20 publications.
Chat about Author
Papers
TERT Promoter Mutations in Familial and Sporadic Melanoma
Susanne Horn,Adina Figl,P. Sivaramakrishna Rachakonda,Christine Fischer,Antje Sucker,Andreas Gast,Stephanie Kadel,Iris Moll,Eduardo Nagore,Kari Hemminki,Kari Hemminki,Dirk Schadendorf,Rajesh Kumar +12 more
TL;DR: A melanoma-prone family through linkage analysis and high-throughput sequencing was investigated and a disease-segregating germline mutation in the promoter of the telomerase reverse transcriptase (TERT) gene, which encodes the catalytic subunit of telomersase, caused up to twofold increase in transcription.
1.7K
Verification of the susceptibility loci on 7p12.2, 10q21.2, and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhood
Rashmi B. Prasad,Fay J. Hosking,Jayaram Vijayakrishnan,Elli Papaemmanuil,Rolf Koehler,Mel Greaves,Eamonn Sheridan,Andreas Gast,Sally E. Kinsey,Tracy Lightfoot,Eve Roman,Malcolm Taylor,Kathy Pritchard-Jones,Martin Stanulla,Martin Schrappe,Claus R. Bartram,Richard S. Houlston,Rajesh Kumar,Kari Hemminki +18 more
TL;DR: The data provide unambiguous evidence for the role of these variants in defining ALL risk underscoring approximately 64% of cases, consistent with a polygenic model of disease susceptibility.
131
Somatic alterations in the melanoma genome: a high-resolution array-based comparative genomic hybridization study.
Andreas Gast,Dominique Scherer,Bowang Chen,Sandra Bloethner,Stephanie Melchert,Antje Sucker,Kari Hemminki,Dirk Schadendorf,Rajesh Kumar +8 more
TL;DR: The data suggest involvement of distinct genetic pathways that are driven either through oncogenic BRAF and NRAS mutations complemented by aberrations in the CDKN2A and PTEN genes or involve amplification ofoncogenic genomic loci and loss of 13q and 16q.
103
Epigenetic deregulation of TCF21 inhibits metastasis suppressor KISS1 in metastatic melanoma
Khelifa Arab,Laura T. Smith,Andreas Gast,Dieter Weichenhan,Joseph Huang,Rainer Claus,Thomas Hielscher,Allan V. Espinosa,Matthew D. Ringel,Carl Morrison,Dirk Schadendorf,Rajesh Kumar,Christoph Plass,Christoph Plass +13 more
TL;DR: Qualitative DNA methylation analysis in patient biopsies and in their derived cell lines is combined to demonstrate that TCF21 expression is downregulated in metastatic melanoma by promoter hypermethylation and TCF 21 promoter DNAmethylation is correlated with decreased survival in metastasis skin melanoma patients.
Association of Inherited Variation in Toll-Like Receptor Genes with Malignant Melanoma Susceptibility and Survival
Andreas Gast,Justo Lorenzo Bermejo,Rainer Claus,Andreas Brandt,Marianne Weires,Alexander N.R. Weber,Christoph Plass,Antje Sucker,Kari Hemminki,Dirk Schadendorf,Rajesh Kumar +10 more
TL;DR: A novel association between TLR gene variants and haplotypes with melanoma survival is found and a role for the D299G polymorphism in the TLR4 gene is suggested in overall survival and a potential link with systemic treatment at stage IV of the disease.