Andreas Claas
German Cancer Research Center
12 Papers
106 Citations
Andreas Claas is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Breast cancer & Gene mapping. The author has an hindex of 10, co-authored 12 publications.
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Papers
Association Between the Rat Homologue of CO-029, a Metastasis-associated Tetraspanin Molecule and Consumption Coagulopathy
TL;DR: The data suggest that the phenomenon of metastasis-associated antigens in the rat could well be associated with the expression of tetraspanin molecules, one of which could be identified as α6β1 integrin.
•Journal Article
Constitutional Genomic Instability with Inversions, Duplications, and Amplifications in 9p23–24 in BRCA2 Mutation Carriers
Larissa Savelyeva,Andreas Claas,Isabel Matzner,Peter M. Schlag,W. Hofmann,Siegfried Scherneck,Barbara L. Weber,Manfred Schwab +7 more
TL;DR: It is established that constitutional distal 9p rearrangements without obvious additional gross chromosomal alterations are a recurrent feature of independently ascertained families, and results raise point to an association of mutant BRCA2 with genomic instability and gene alteration in 9p23-24 in at least a subset of BRCa2 mutation carriers.
•Journal Article
Two Regions of Deletion in 9p23–24 in Sporadic Breast Cancer
Han Xiang An,Andreas Claas,Larissa Savelyeva,Susanne Seitz,Peter M. Schlag,Siegfried Scherneck,Manfred Schwab +6 more
TL;DR: To find out whether this genomic region is involved more frequently in alterations in sporadic breast cancers, 80 microdissected tumor samples are surveyed for both loss of heterozygosity (LOH) and homozygous deletion at 22 microsatellite loci spanning 9p22 to 9p24 using fluorescent multiplex PCR.
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BRCA2: a genetic risk factor for breast cancer
TL;DR: Central questions have remained unanswered: What is the function of damaged BRCA1 and BRCa2 genes in breast cancer risk?
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Retention of polysomy at 9p23-24 during karyotypic evolution in human breast cancer cell line COLO 824.
TL;DR: The approximately tenfold increase in copy number of DNA from 9p23–24, which is far distal to P16/CDKN2A in female breast cancer cell line COLO 824, is reported, as revealed by fluorescence in situ Hybridization, comparative genomic hybridization, and microsatellite analysis.
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