Andreas Busche
Hannover Medical School
15 Papers
142 Citations
Andreas Busche is an academic researcher from Hannover Medical School. The author has contributed to research in topics: Cytotoxic T cell & CD8. The author has an hindex of 11, co-authored 14 publications.
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Papers
In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity
Stephan Halle,Kirsten A. Keyser,Felix R. Stahl,Andreas Busche,Anja Marquardt,Xiang Zheng,Melanie Galla,Vigo Heissmeyer,Katrin Heller,Jasmin Boelter,Karen Wagner,Yvonne Bischoff,Rieke Martens,Asolina Braun,Kathrin Werth,Alexey Uvarovskii,Harald Kempf,Michael Meyer-Hermann,Ramon Arens,Melanie Kremer,Gerd Sutter,Martin Messerle,Reinhold Förster +22 more
TL;DR: Direct visualization of CTLs during killing of virus-infected cells reveals crucial parameters of CD8+ T cell immunity.
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Priming of CD8(+) T Cells against Cytomegalovirus-Encoded Antigens Is Dominated by Cross-Presentation
Andreas Busche,Adan Chari Jirmo,Suzanne P. M. Welten,Jasmin Zischke,Julia Noack,Hannelore Constabel,Anna-Katherina Gatzke,Kirsten A. Keyser,Ramon Arens,Georg M. N. Behrens,Martin Messerle +10 more
TL;DR: It is concluded that the host uses mainly DCs capable of cross-presentation to induce the CMV-specific CD8+ T cell response during primary, acute infection and discusses the implications for the development of a CMV vaccine.
Reversible Inhibition of Murine Cytomegalovirus Replication by Gamma Interferon (IFN-γ) in Primary Macrophages Involves a Primed Type I IFN-Signaling Subnetwork for Full Establishment of an Immediate-Early Antiviral State
Kai A. Kropp,Kevin A. Robertson,Garwin Sing,Sara Rodríguez-Martín,Mathieu Blanc,Paul Lacaze,Muhamad F. B. Noor Hassim,Mizanur Khondoker,Andreas Busche,Paul Dickinson,Thorsten Forster,Birgit Strobl,Mathias Mueller,Stipan Jonjić,Ana Angulo,Peter Ghazal +15 more
TL;DR: The results show that a primed type I IFN subnetwork contributes to an immediate-early antiviral state induced by type II IFN activation of macrophages, with a potential further amplification loop contributed by transient induction of IFN-β.
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Phenotypes of major immediate-early gene mutants of mouse cytomegalovirus.
TL;DR: This work constructed mouse CMV mutants with disruptions in the major IE genes, ie1 and ie3, to study the roles of these genes in the context of the viral infection.
Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1γ
Tihana Tršan,Andreas Busche,Maja Abram,Felix M. Wensveen,Niels A. W. Lemmermann,Maja Arapović,Marina Babić,Adriana Tomic,Mijo Golemac,Melanie M. Brinkmann,Wiebke Jäger,Annette Oxenius,Bojan Polić,Astrid Krmpotić,Martin Messerle,Stipan Jonjić +15 more
TL;DR: It is demonstrated that a recombinant CMV vector expressing RAE-1γ, a cellular ligand for activating NKG2D receptor expressed on several types of immune cells, has tremendous potential for subverting viral immunoevasion and enhancing the efficiency of the CD8 T-cell response against vectored antigens.
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